Abstract
We were able to obtain 2-cyanoquinazolin-4(3H)-ones 11 in 35-60% four-step overall isolated yields and 2,3-dihydrooxazolo[2,3-b]quinazolin-5-ones 12 in 20-71% four-step overall isolated yields utilizing polymer-bound anthranilic acid derivatives 1, and 6-amino-2-cyanoquinazolin-4(3H)-ones 19 in 30-44% six-step overall isolated yields making use of anthranilic acid derivative resin 2 via dithiazole resins 10 and 17. The reactions on solid phase were monitored by single bead ATR-FTIR spectroscopic method.
Original language | English |
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Pages (from-to) | 7477-7481 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 44 |
DOIs | |
Publication status | Published - 2005 Oct 31 |
Keywords
- Anthranilic acid
- Dithiazole
- Quinazolinone
- Solid-phase synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry