Abstract
The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents (see microscopy image). (Chemical equation presented).
Original language | English |
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Pages (from-to) | 6331-6335 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 43 |
Issue number | 46 |
DOIs | |
Publication status | Published - 2004 Nov 26 |
Externally published | Yes |
Keywords
- Combinatorial chemistry
- Dyes/pigments
- Fluorescent probes
- Imaging agents
- Solid-phase synthesis
ASJC Scopus subject areas
- Catalysis
- General Chemistry