Solid-phase synthesis of styryl dyes and their application as amyloid sensors

Qian Li; Jun Seok Lee; Chanki Ha; Beum Park Chan; Guang Yang; Biao Gan Wen; Young Tae Chang

doi:10.1002/anie.200461600

Solid-phase synthesis of styryl dyes and their application as amyloid sensors

Qian Li, Jun Seok Lee, Chanki Ha, Beum Park Chan, Guang Yang, Biao Gan Wen, Young Tae Chang

Research output: Contribution to journal › Article › peer-review

107 Citations (Scopus)

Abstract

The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents (see microscopy image). (Chemical equation presented).

Original language	English
Pages (from-to)	6331-6335
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	46
DOIs	https://doi.org/10.1002/anie.200461600
Publication status	Published - 2004 Nov 26
Externally published	Yes

Keywords

Combinatorial chemistry
Dyes/pigments
Fluorescent probes
Imaging agents
Solid-phase synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200461600

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abstract = "The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents (see microscopy image). (Chemical equation presented).",

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AU - Li, Qian

AU - Lee, Jun Seok

AU - Ha, Chanki

AU - Chan, Beum Park

AU - Yang, Guang

AU - Wen, Biao Gan

AU - Chang, Young Tae

PY - 2004/11/26

Y1 - 2004/11/26

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AB - The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents (see microscopy image). (Chemical equation presented).

KW - Combinatorial chemistry

KW - Dyes/pigments

KW - Fluorescent probes

KW - Imaging agents

KW - Solid-phase synthesis

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U2 - 10.1002/anie.200461600

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ER -

Solid-phase synthesis of styryl dyes and their application as amyloid sensors

Abstract

Keywords

ASJC Scopus subject areas

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