Abstract
The reaction efficiency and enantioselectivity of an asymmetric Pauson-Khand-type reaction catalyzed by cationic rhodium are heavily dependent on the solvent. Coordinating solvents, such as THF, provide a faster reaction and better stereoselectivity than non-coordinating solvents, such as toluene. These beneficial effects can be attributed to a significant increase in the more reactive catalytic species of [Rh(bisphosphane ligand)*(solvent)n]+ (3) than of [Rh(bisphosphine ligand)*CO(solvent)]+(4) and [Rh(bisphosphine ligand)*(CO)2]+ (5) in a coordinating solvent.
Original language | English |
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Pages (from-to) | 6068-6071 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 44 |
DOIs | |
Publication status | Published - 2009 Nov 4 |
Keywords
- Chiral THF derivatives
- Enantioselective
- Pauson-Khand reaction
- Rhodium
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry