TY - JOUR
T1 - Soochong virus
T2 - An antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea
AU - Baek, Luck Ju
AU - Kariwa, Hiroaki
AU - Lokugamage, Kumari
AU - Yoshimatsu, Kumiko
AU - Arikawa, Jiro
AU - Takashima, Ikuo
AU - Kang, Ju Il
AU - Moon, Sung Sil
AU - Chung, Su Yong
AU - Kim, Eun Ju
AU - Kang, Hae Ji
AU - Song, Ki Joon
AU - Klein, Terry A.
AU - Yanagihara, Richard
AU - Song, Jin Won
PY - 2006/2
Y1 - 2006/2
N2 - Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissue of a striped-field mouse (Apodemus agrarius) captured in Songnae-ri, Gyeonggi Province, Republic of Korea. Found primarily in mountainous areas, the Korean field mouse (A peninsulae) is the second-most dominant field rodent species found throughout Korea. A new hantavirus, designated Soochong (SOO), was isolated in Vero E6 cells from four A. peninsulae captured in August 1997 at Mt. Gyebang in Hongcheon-gun, Mt. Gachil, Inje-gun, Gangwon Province, and in September 1998 at Mt. Deogyu, Muju-gun, Jeollabuk Province. The entire S, M, and L genomic segments of SOO virus, amplified by RT-PCR from lung tissues of seropositive A peninsulae and from virus-infected Vero E6 cells, diverged from HTN virus (strain 76-118) by 15.6%, 22.8%, and 21.7% at the nucleotide level and 3.5%, 9.5%, and 4.6% at the amino acid level, respectively. Phylogenetic analyses of the nucleotide and deduced amino acid sequences, using the maximum parsimony and neighbor-joining methods, indicated that SOO virus was distinct from A agrarius-borne HTN virus. SOO virus shared a common ancestry with Amur virus from Far East Russia, as well as with H5 and B78 hantaviruses, previously isolated from HFRS patients in China. Cross-focus-reduction neutralizating antibody tests showed that SOO virus, which is the first hantavirus isolated in cell culture from A peninsulae, could be classified as a new hantavirus serotype.
AB - Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissue of a striped-field mouse (Apodemus agrarius) captured in Songnae-ri, Gyeonggi Province, Republic of Korea. Found primarily in mountainous areas, the Korean field mouse (A peninsulae) is the second-most dominant field rodent species found throughout Korea. A new hantavirus, designated Soochong (SOO), was isolated in Vero E6 cells from four A. peninsulae captured in August 1997 at Mt. Gyebang in Hongcheon-gun, Mt. Gachil, Inje-gun, Gangwon Province, and in September 1998 at Mt. Deogyu, Muju-gun, Jeollabuk Province. The entire S, M, and L genomic segments of SOO virus, amplified by RT-PCR from lung tissues of seropositive A peninsulae and from virus-infected Vero E6 cells, diverged from HTN virus (strain 76-118) by 15.6%, 22.8%, and 21.7% at the nucleotide level and 3.5%, 9.5%, and 4.6% at the amino acid level, respectively. Phylogenetic analyses of the nucleotide and deduced amino acid sequences, using the maximum parsimony and neighbor-joining methods, indicated that SOO virus was distinct from A agrarius-borne HTN virus. SOO virus shared a common ancestry with Amur virus from Far East Russia, as well as with H5 and B78 hantaviruses, previously isolated from HFRS patients in China. Cross-focus-reduction neutralizating antibody tests showed that SOO virus, which is the first hantavirus isolated in cell culture from A peninsulae, could be classified as a new hantavirus serotype.
KW - Apodemus peninsulae
KW - HFRS
KW - Hantavirus
KW - Soochong virus
UR - http://www.scopus.com/inward/record.url?scp=31144466313&partnerID=8YFLogxK
U2 - 10.1002/jmv.20538
DO - 10.1002/jmv.20538
M3 - Article
C2 - 16372283
AN - SCOPUS:31144466313
SN - 0146-6615
VL - 78
SP - 290
EP - 297
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 2
ER -
