SP-8356 inhibits acute lung injury by suppressing inflammatory cytokine production and immune cell infiltration

Thai Uy Nguyen, Sunghoon Hurh, Soyeon In, Lan Phuong Nguyen, Minyeong Cho, Kateryna Mykhailova, Hong Rae Kim, Byung Joo Ham, Yongseok Choi, Won Ki Kim, Jong Ik Hwang

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated the anti-inflammatory and protective properties of SP-8356, a synthetic derivative of (1S)-(-)-verbenone, in a mouse model of LPS-induced acute lung injury (ALI). By targeting intracellular signaling pathways and inflammatory responses, SP-8356 demonstrated a potent ability to attenuate deleterious effects of proinflammatory stimuli. Specifically, SP-8356 effectively inhibited the activation of crucial signaling molecules such as NF-κB and Akt, and subsequently dampened the expression of inflammatory cytokines in various lung cellular components. Intervention with SP-8356 treatment also preserved the structural integrity of the epithelial and endothelial barriers. By reducing immune cell infiltration into inflamed lung tissue, SP-8356 exerted a broad protective effect against ALI. These findings position SP-8356 as a promising therapeutic candidate for pulmonary inflammatory diseases that cause ALI.

Original languageEnglish
Article number111847
JournalInternational Immunopharmacology
Volume131
DOIs
Publication statusPublished - 2024 Apr 20

Bibliographical note

Publisher Copyright:
© 2024 Elsevier B.V.

Keywords

  • Acute lung injury
  • Inflammatory cytokines
  • LPS
  • NF-κB
  • SP-8356

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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