Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat

Il Hwan Kim; Soon Kwon Park; Woong Sun; Yunhee Kang; Hyun Taek Kim; Hyun Kim

doi:10.1016/j.molbrainres.2003.12.016

Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat

Il Hwan Kim, Soon Kwon Park, Woong Sun, Yunhee Kang, Hyun Taek Kim, Hyun Kim

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP₃K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP₃) to inositol 1,3,4,5- tetrakisphosphate (IP₄). Because IP₃K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP₃K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP ₃K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP₃K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP₃K-A mRNA was maintained until the fifth day of training. These results suggest that IP ₃K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.

Original language	English
Pages (from-to)	12-19
Number of pages	8
Journal	Molecular Brain Research
Volume	124
Issue number	1
DOIs	https://doi.org/10.1016/j.molbrainres.2003.12.016
Publication status	Published - 2004 Apr 29

Bibliographical note

Funding Information:
We thank Dr. Sangduk Kim for valuable comments on the manuscript and Mr. J. Jung for assistants. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ1-PG1-CH06-0001).

Keywords

Hippocampal formation
Inositol 1,4,5-trisphosphate 3-kinase A
Learning and memory: systems and functions - animals
Neural basis of behavior
Spatial learning

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/j.molbrainres.2003.12.016

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title = "Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat",

abstract = "Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5- tetrakisphosphate (IP4). Because IP3K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP3K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP 3K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP3K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP3K-A mRNA was maintained until the fifth day of training. These results suggest that IP 3K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.",

keywords = "Hippocampal formation, Inositol 1,4,5-trisphosphate 3-kinase A, Learning and memory: systems and functions - animals, Neural basis of behavior, Spatial learning",

author = "Kim, {Il Hwan} and Park, {Soon Kwon} and Woong Sun and Yunhee Kang and Kim, {Hyun Taek} and Hyun Kim",

note = "Funding Information: We thank Dr. Sangduk Kim for valuable comments on the manuscript and Mr. J. Jung for assistants. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ1-PG1-CH06-0001).",

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doi = "10.1016/j.molbrainres.2003.12.016",

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AU - Kim, Il Hwan

AU - Park, Soon Kwon

AU - Sun, Woong

AU - Kang, Yunhee

AU - Kim, Hyun Taek

AU - Kim, Hyun

N1 - Funding Information: We thank Dr. Sangduk Kim for valuable comments on the manuscript and Mr. J. Jung for assistants. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ1-PG1-CH06-0001).

PY - 2004/4/29

Y1 - 2004/4/29

N2 - Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5- tetrakisphosphate (IP4). Because IP3K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP3K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP 3K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP3K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP3K-A mRNA was maintained until the fifth day of training. These results suggest that IP 3K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.

AB - Calcium-mediated signaling is crucial for the synaptic plasticity and long-term memory storage, which requires de novo protein synthesis. Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is an enzyme, which is involved in the maintenance of intracellular calcium homeostasis by converting inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5- tetrakisphosphate (IP4). Because IP3K-A is enriched in the dendritic spines of hippocampal neurons, it has been speculated that this enzyme is involved in the memory formation. In the present study, we demonstrated that the expression of IP3K-A is increased in the hippocampal formation of the rats during the Morris water maze training. Immunohistochemical analysis indicated the specific induction of IP 3K-A protein in the hippocampal formation following 5-day water maze training. Furthermore, in situ hybridization histochemistry showed that the induction of IP3K-A mRNA in the hippocampal formation was observed on the first day of training, and the induced level of IP3K-A mRNA was maintained until the fifth day of training. These results suggest that IP 3K-A plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation.

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KW - Inositol 1,4,5-trisphosphate 3-kinase A

KW - Learning and memory: systems and functions - animals

KW - Neural basis of behavior

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ER -

Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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