TY - JOUR
T1 - Spatial-temporal event adaptive characteristics of nanocarrier drug delivery in cancer therapy
AU - Kong, Ming
AU - Park, Hyunjin
AU - Cheng, Xiaojie
AU - Chen, Xiguang
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China ( 31300786 , 31240007 ), Shandong Youth Scientist Awards Foundation ( BS2012SW024 ) and Programs Foundation of Ministry of Education of China ( 20120132120011 ).
PY - 2013
Y1 - 2013
N2 - In cancer therapy, drug delivery is a complex process that aims to transit the cargo to the destination with as little damage to the normal tissue as possible. In the last decade, tremendous development and research on nanomedicine have been exploring an ideal system with efficient drug transportation and release property. For this end, series of barriers need to be circumvented by nanomedicine, including systemic barriers, such as biosurface adsorption, phagocytic clearance, bloodstream washing, interstitial pressure, degradation, as well as intracellular barriers, such as cell membrane reorganization and internalization, endo/lysosomal escape, cytosolic or subcellular localization. Rather than being random, these barriers follow a specific spatial-temporal sequence. Therefore, the nanocarriers have to be endowed with characteristics that are adaptive to particular biological milieu on systemic and intracellular levels. To this end, we reviewed the correlations between the spatial-temporal sequences of drug delivery and nanocarrier characteristics in cancer therapy, as well as strategies to achieve efficient drug delivery upon both systemic and intracellular levels.
AB - In cancer therapy, drug delivery is a complex process that aims to transit the cargo to the destination with as little damage to the normal tissue as possible. In the last decade, tremendous development and research on nanomedicine have been exploring an ideal system with efficient drug transportation and release property. For this end, series of barriers need to be circumvented by nanomedicine, including systemic barriers, such as biosurface adsorption, phagocytic clearance, bloodstream washing, interstitial pressure, degradation, as well as intracellular barriers, such as cell membrane reorganization and internalization, endo/lysosomal escape, cytosolic or subcellular localization. Rather than being random, these barriers follow a specific spatial-temporal sequence. Therefore, the nanocarriers have to be endowed with characteristics that are adaptive to particular biological milieu on systemic and intracellular levels. To this end, we reviewed the correlations between the spatial-temporal sequences of drug delivery and nanocarrier characteristics in cancer therapy, as well as strategies to achieve efficient drug delivery upon both systemic and intracellular levels.
KW - Drug delivery
KW - Intracellular targeting
KW - Spatial-temporal sequence
KW - Stimuli-responsive
KW - Systemic targeting
UR - http://www.scopus.com/inward/record.url?scp=84884296204&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2013.08.022
DO - 10.1016/j.jconrel.2013.08.022
M3 - Review article
C2 - 24004884
AN - SCOPUS:84884296204
SN - 0168-3659
VL - 172
SP - 281
EP - 291
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -