Spatial-temporal event adaptive characteristics of nanocarrier drug delivery in cancer therapy

Ming Kong, Hyunjin Park, Xiaojie Cheng, Xiguang Chen

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


In cancer therapy, drug delivery is a complex process that aims to transit the cargo to the destination with as little damage to the normal tissue as possible. In the last decade, tremendous development and research on nanomedicine have been exploring an ideal system with efficient drug transportation and release property. For this end, series of barriers need to be circumvented by nanomedicine, including systemic barriers, such as biosurface adsorption, phagocytic clearance, bloodstream washing, interstitial pressure, degradation, as well as intracellular barriers, such as cell membrane reorganization and internalization, endo/lysosomal escape, cytosolic or subcellular localization. Rather than being random, these barriers follow a specific spatial-temporal sequence. Therefore, the nanocarriers have to be endowed with characteristics that are adaptive to particular biological milieu on systemic and intracellular levels. To this end, we reviewed the correlations between the spatial-temporal sequences of drug delivery and nanocarrier characteristics in cancer therapy, as well as strategies to achieve efficient drug delivery upon both systemic and intracellular levels.

Original languageEnglish
Pages (from-to)281-291
Number of pages11
JournalJournal of Controlled Release
Issue number1
Publication statusPublished - 2013

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China ( 31300786 , 31240007 ), Shandong Youth Scientist Awards Foundation ( BS2012SW024 ) and Programs Foundation of Ministry of Education of China ( 20120132120011 ).


  • Drug delivery
  • Intracellular targeting
  • Spatial-temporal sequence
  • Stimuli-responsive
  • Systemic targeting

ASJC Scopus subject areas

  • Pharmaceutical Science


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