Spatio-angular consistent construction of neonatal diffusion MRI atlases

Behrouz Saghafi, Jaeil Kim, Geng Chen, Feng Shi, Weili Lin, Pew Thian Yap, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Atlases constructed using diffusion-weighted imaging are important tools for studying human brain development. Atlas construction is in general a two-step process involving spatial registration and fusion of individual images. The focus of most studies so far has been on improving the accuracy of registration while image fusion is commonly performed using simple averaging, often resulting in fuzzy atlases. In this article, we propose a patch-based method for diffusion-weighted (DW) atlas construction. Unlike other atlases that are based on the diffusion tensor model, our atlas is model-free and generated directly from the diffusion-weighted images. Instead of independently generating an atlas for each gradient direction and hence neglecting angular image correlation, we propose to construct the atlas by jointly considering DW images of neighboring gradient directions. We employ a group regularization framework where local patches of angularly neighboring images are constrained for consistent spatio-angular atlas reconstruction. Experimental results confirm that our atlas, constructed for neonatal data, reveals more structural details with higher fractional anisotropy than the atlas generated without angular consistency as well as the average atlas. Also the normalization of test subjects to the proposed atlas results in better alignment of brain structures. Hum Brain Mapp 38:3175–3189, 2017.

Original languageEnglish
Pages (from-to)3175-3189
Number of pages15
JournalHuman Brain Mapping
Issue number6
Publication statusPublished - 2017 Jun

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.


  • diffusion MRI
  • multi-task learning
  • neonatal brain atlases
  • sparse representation
  • spatio-angular consistency

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


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