Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease

S. K. Jo; A. Bajwa; A. S. Awad; K. R. Lynch; M. D. Okusa

doi:10.1038/ki.2008.34

Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease

S. K. Jo, A. Bajwa, A. S. Awad, K. R. Lynch, M. D. Okusa

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions. S1P is the ligand for a family of five G-protein-coupled receptors with distinct signaling pathways that regulate angiogenesis, vascular maturation, immunity, chemotaxis, and other important biological pathways. Recently, clinical trials have targeted S1P receptors (S1PRs) for autoimmune diseases and transplantation and have generated considerable interest in developing additional, more selective compounds. This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease.

Original language	English
Pages (from-to)	1220-1230
Number of pages	11
Journal	Kidney International
Volume	73
Issue number	11
DOIs	https://doi.org/10.1038/ki.2008.34
Publication status	Published - 2008 Jun
Externally published	Yes

Keywords

Acute kidney injury
FTY720
Ischemia-reperfusion injury
S1P
SEW2871
Sphingolipid

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2008.34

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title = "Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease",

abstract = "The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions. S1P is the ligand for a family of five G-protein-coupled receptors with distinct signaling pathways that regulate angiogenesis, vascular maturation, immunity, chemotaxis, and other important biological pathways. Recently, clinical trials have targeted S1P receptors (S1PRs) for autoimmune diseases and transplantation and have generated considerable interest in developing additional, more selective compounds. This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease.",

keywords = "Acute kidney injury, FTY720, Ischemia-reperfusion injury, S1P, SEW2871, Sphingolipid",

author = "Jo, {S. K.} and A. Bajwa and Awad, {A. S.} and Lynch, {K. R.} and Okusa, {M. D.}",

note = "Funding Information: We gratefully acknowledge Hong Ye and Michael Rouse for expert technical assistance, Dr Timothy Macdonald (Department of Chemistry, University of Virginia) for providing VPC44116, Drs Diane L Rosin (Department of Pharmacology, University of Virginia) and Konstantine Kutshivili (Department of Medicine, University of Virginia) for careful reading of the manuscript, and Steven P Song for artwork. This work was supported by grants from the National Institutes of Health RO1 DK56223, RO1 DK62324, RO1 DK065957, and R01GM067958.",

year = "2008",

month = jun,

doi = "10.1038/ki.2008.34",

language = "English",

volume = "73",

pages = "1220--1230",

journal = "Kidney International",

issn = "0085-2538",

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T2 - Biology and therapeutic potential in kidney disease

AU - Jo, S. K.

AU - Bajwa, A.

AU - Awad, A. S.

AU - Lynch, K. R.

AU - Okusa, M. D.

N1 - Funding Information: We gratefully acknowledge Hong Ye and Michael Rouse for expert technical assistance, Dr Timothy Macdonald (Department of Chemistry, University of Virginia) for providing VPC44116, Drs Diane L Rosin (Department of Pharmacology, University of Virginia) and Konstantine Kutshivili (Department of Medicine, University of Virginia) for careful reading of the manuscript, and Steven P Song for artwork. This work was supported by grants from the National Institutes of Health RO1 DK56223, RO1 DK62324, RO1 DK065957, and R01GM067958.

PY - 2008/6

Y1 - 2008/6

N2 - The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions. S1P is the ligand for a family of five G-protein-coupled receptors with distinct signaling pathways that regulate angiogenesis, vascular maturation, immunity, chemotaxis, and other important biological pathways. Recently, clinical trials have targeted S1P receptors (S1PRs) for autoimmune diseases and transplantation and have generated considerable interest in developing additional, more selective compounds. This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease.

AB - The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions. S1P is the ligand for a family of five G-protein-coupled receptors with distinct signaling pathways that regulate angiogenesis, vascular maturation, immunity, chemotaxis, and other important biological pathways. Recently, clinical trials have targeted S1P receptors (S1PRs) for autoimmune diseases and transplantation and have generated considerable interest in developing additional, more selective compounds. This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease.

KW - Acute kidney injury

KW - FTY720

KW - Ischemia-reperfusion injury

KW - S1P

KW - SEW2871

KW - Sphingolipid

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JO - Kidney International

JF - Kidney International

IS - 11

ER -

Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease

Abstract

Keywords

ASJC Scopus subject areas

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