Spontaneous resolution of post-transplant localized cytomegalovirus lymphadenitis mimicking tumor recurrence

K. W. Kang, J. H. Lee, J. S. Choi, S. R. Lee, Y. Park, B. S. Kim, I. Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Compromised T-cell immunity persists for up to 1 year after autologous stem cell transplantation (ASCT), and patients treated with ASCT are more likely to develop atypical lymphoid hyperplasia that mimics tumor recurrence. Here, we present a case of cervical lymphadenitis due to cytomegalovirus (CMV) reactivation in a patient who had undergone ASCT for Burkitt lymphoma, which mimicked tumor recurrence on computed tomography and positron emission tomography-computed tomography 6 months after ASCT. This lesion was confined to the regional lymph nodes and was not accompanied by signs of systemic involvement, such as fever, splenomegaly, an elevated C-reactive protein level, or viremia. The localized CMV lymphadenitis resolved spontaneously without treatment after 6 months (12 months after ASCT) and the elevated CMV immunoglobulin-M titer normalized 6 months after resolution. Our experience with this case suggests that cautious follow-up without anti-CMV treatment should be considered in cases of post-ASCT localized CMV lymphadenitis without systemic involvement in patients with complete engraftment.

Original languageEnglish
Pages (from-to)676-680
Number of pages5
JournalTransplant Infectious Disease
Issue number4
Publication statusPublished - 2014 Aug


  • Atypical lymphoid hyperplasia
  • Autologous stem cell transplantation
  • CMV
  • Cytomegalovirus lymphadenitis

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation


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