TY - JOUR
T1 - Squeezing hydrogels for controlled oral drug delivery
AU - Gutowska, Anna
AU - Bark, Jong Seok
AU - Kwon, Ick Chan
AU - Bae, You Han
AU - Cha, Younsik
AU - Kim, Sung Wan
N1 - Funding Information:
The authors wish to thank Dr. H. Jacobs for helpful discussions. This work was supported by MacroMed Inc., Salt Lake City, Utah.
PY - 1997/10/13
Y1 - 1997/10/13
N2 - A new delivery device based on a novel, squeezing hydrogel concept, utilizing specific swelling-deswelling characteristics of temperature-, temperature/pH- and pH -sensitive hydrogels is described. These hydrogels have been designed to exhibit controlled swelling-deswelling kinetics, hence, a variety of release profiles may be generated including: delayed, zero-order or on-off release profiles. A temperature sensitive NiPAAm/AAc hydrogel demonstrated a squeezing controlled 'on-off' release profile in response to a temperature change between 35°and 40°C with the 'on' phase at higher temperature. Drug release profiles from a pH/T sensitive NiPAAm/BMA/DEAEMA hydrogel were strongly affected by a pH change at 37°C. The gel demonstrated a minimal delayed release at pH 2.0 and a zero-order release at pH 7.4 controlled by mechanical squeezing mechanism that was determined by the gel deswelling kinetics. A delayed and a zero-order release profiles were also obtained for a pH sensitive cationic hydrogel in response to a pH change from pH 2.0 to 7.4. For all studied systems, it was concluded that a gel composition and an applied stimuli (T, pH, pH/T), determined the gel swelling/deswelling kinetics and the release profiles.
AB - A new delivery device based on a novel, squeezing hydrogel concept, utilizing specific swelling-deswelling characteristics of temperature-, temperature/pH- and pH -sensitive hydrogels is described. These hydrogels have been designed to exhibit controlled swelling-deswelling kinetics, hence, a variety of release profiles may be generated including: delayed, zero-order or on-off release profiles. A temperature sensitive NiPAAm/AAc hydrogel demonstrated a squeezing controlled 'on-off' release profile in response to a temperature change between 35°and 40°C with the 'on' phase at higher temperature. Drug release profiles from a pH/T sensitive NiPAAm/BMA/DEAEMA hydrogel were strongly affected by a pH change at 37°C. The gel demonstrated a minimal delayed release at pH 2.0 and a zero-order release at pH 7.4 controlled by mechanical squeezing mechanism that was determined by the gel deswelling kinetics. A delayed and a zero-order release profiles were also obtained for a pH sensitive cationic hydrogel in response to a pH change from pH 2.0 to 7.4. For all studied systems, it was concluded that a gel composition and an applied stimuli (T, pH, pH/T), determined the gel swelling/deswelling kinetics and the release profiles.
KW - Controlled oral drug delivery
KW - Drug delivery device
KW - Swelling/deswelling kinetics
KW - Temperature-sensitive hydrogels
KW - pH-Sensitive hydrogels
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U2 - 10.1016/S0168-3659(97)00041-2
DO - 10.1016/S0168-3659(97)00041-2
M3 - Article
AN - SCOPUS:0030761148
SN - 0168-3659
VL - 48
SP - 141
EP - 148
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2-3
ER -