Squeezing hydrogels for controlled oral drug delivery

Anna Gutowska; Jong Seok Bark; Ick Chan Kwon; You Han Bae; Younsik Cha; Sung Wan Kim

doi:10.1016/S0168-3659(97)00041-2

Squeezing hydrogels for controlled oral drug delivery

Anna Gutowska, Jong Seok Bark, Ick Chan Kwon, You Han Bae, Younsik Cha, Sung Wan Kim

Research output: Contribution to journal › Article › peer-review

171 Citations (Scopus)

Abstract

A new delivery device based on a novel, squeezing hydrogel concept, utilizing specific swelling-deswelling characteristics of temperature-, temperature/pH- and pH -sensitive hydrogels is described. These hydrogels have been designed to exhibit controlled swelling-deswelling kinetics, hence, a variety of release profiles may be generated including: delayed, zero-order or on-off release profiles. A temperature sensitive NiPAAm/AAc hydrogel demonstrated a squeezing controlled 'on-off' release profile in response to a temperature change between 35°and 40°C with the 'on' phase at higher temperature. Drug release profiles from a pH/T sensitive NiPAAm/BMA/DEAEMA hydrogel were strongly affected by a pH change at 37°C. The gel demonstrated a minimal delayed release at pH 2.0 and a zero-order release at pH 7.4 controlled by mechanical squeezing mechanism that was determined by the gel deswelling kinetics. A delayed and a zero-order release profiles were also obtained for a pH sensitive cationic hydrogel in response to a pH change from pH 2.0 to 7.4. For all studied systems, it was concluded that a gel composition and an applied stimuli (T, pH, pH/T), determined the gel swelling/deswelling kinetics and the release profiles.

Original language	English
Pages (from-to)	141-148
Number of pages	8
Journal	Journal of Controlled Release
Volume	48
Issue number	2-3
DOIs	https://doi.org/10.1016/S0168-3659(97)00041-2
Publication status	Published - 1997 Oct 13

Bibliographical note

Funding Information:
The authors wish to thank Dr. H. Jacobs for helpful discussions. This work was supported by MacroMed Inc., Salt Lake City, Utah.

Keywords

Controlled oral drug delivery
Drug delivery device
Swelling/deswelling kinetics
Temperature-sensitive hydrogels
pH-Sensitive hydrogels

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/S0168-3659(97)00041-2

Cite this

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title = "Squeezing hydrogels for controlled oral drug delivery",

abstract = "A new delivery device based on a novel, squeezing hydrogel concept, utilizing specific swelling-deswelling characteristics of temperature-, temperature/pH- and pH -sensitive hydrogels is described. These hydrogels have been designed to exhibit controlled swelling-deswelling kinetics, hence, a variety of release profiles may be generated including: delayed, zero-order or on-off release profiles. A temperature sensitive NiPAAm/AAc hydrogel demonstrated a squeezing controlled 'on-off' release profile in response to a temperature change between 35°and 40°C with the 'on' phase at higher temperature. Drug release profiles from a pH/T sensitive NiPAAm/BMA/DEAEMA hydrogel were strongly affected by a pH change at 37°C. The gel demonstrated a minimal delayed release at pH 2.0 and a zero-order release at pH 7.4 controlled by mechanical squeezing mechanism that was determined by the gel deswelling kinetics. A delayed and a zero-order release profiles were also obtained for a pH sensitive cationic hydrogel in response to a pH change from pH 2.0 to 7.4. For all studied systems, it was concluded that a gel composition and an applied stimuli (T, pH, pH/T), determined the gel swelling/deswelling kinetics and the release profiles.",

keywords = "Controlled oral drug delivery, Drug delivery device, Swelling/deswelling kinetics, Temperature-sensitive hydrogels, pH-Sensitive hydrogels",

author = "Anna Gutowska and Bark, {Jong Seok} and Kwon, {Ick Chan} and Bae, {You Han} and Younsik Cha and Kim, {Sung Wan}",

note = "Funding Information: The authors wish to thank Dr. H. Jacobs for helpful discussions. This work was supported by MacroMed Inc., Salt Lake City, Utah.",

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AU - Bark, Jong Seok

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AU - Bae, You Han

AU - Cha, Younsik

AU - Kim, Sung Wan

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Squeezing hydrogels for controlled oral drug delivery

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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