Src family kinases as mediators of endothelial permeability: Effects on inflammation and metastasis

M. P. Kim, S. I. Park, S. Kopetz, G. E. Gallick

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)

Abstract

Src family kinases (SFKs) are signaling enzymes that have long been recognized to regulate critical cellular processes such as proliferation, survival, migration, and metastasis. Recently, considerable work has elucidated mechanisms by which SFKs regulate normal and pathologic processes in vascular biology, including endothelial cell proliferation and permeability. Further, when inappropriately activated, SFKs promote pathologic inflammatory processes and tumor metastasis, in part through their effects on the regulation of endothelial monolayer permeability. In this review, we discuss the roles of aberrantly activated SFKs in mediating endothelial permeability in the context of inflammatory states and tumor cell metastasis. We further summarize recent efforts to translate Src-specific inhibitors into therapy for systemic inflammatory conditions and numerous solid organ cancers.

Original languageEnglish
Pages (from-to)249-259
Number of pages11
JournalCell and Tissue Research
Volume335
Issue number1
DOIs
Publication statusPublished - 2009 Jan
Externally publishedYes

Bibliographical note

Funding Information:
The authors’ own research was supported in part by NIH U54 CA 090810 and P20 CA101936 (G.E.G) and NIH T32 CA 09599 (M.P.K.) M.P.Kim.S.I.Park.S.Kopetz.G.E.Gallick(*) Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box no. 173, Houston, TX 77030–4009, USA e-mail: ggallick@mdanderson.org

Keywords

  • Inflammation
  • Inhibitors
  • Metastasis
  • Src family kinases
  • Tumor progression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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