Stabilin receptors: Role as phosphatidylserine receptors

Seung Yoon Park, In San Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) and cell fusion, and their ligand-recognition and signaling pathways.

Original languageEnglish
Article number387
JournalBiomolecules
Volume9
Issue number8
DOIs
Publication statusPublished - 2019 Aug

Bibliographical note

Funding Information:
Funding: The National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2017R1A3B1023418), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2017R1A2B4002662), the KU-KIST Graduate School of Converging Science and Technology Program, and the KIST Institutional Program.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Efferocytosis
  • Fusion
  • Phosphatidylserine
  • Stabilin-1
  • Stabilin-2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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