Stability and cellular responses to fluorapatite-collagen composites

Byung Ho Yoon, Hae Won Kim, Su Hee Lee, Chang Jun Bae, Young Hag Koh, Young Min Kong, Hyoun Ee Kim

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)


Fluorapatite (FA)-collagen composites were synthesized via a biomimetic coprecipitation method in order to improve the structural stability and cellular responses. Different amounts of ammonium fluoride (NH 4F), acting as a fluorine source for FA, were added to the precipitation of the composites. The precipitated composites were freeze-dried and isostatically pressed in a dense body. The added fluorine was incorporated nearly fully into the apatite structure (fluoridation), and a near stoichiometric FA-collagen composite was obtained with complete fluoridation. The freeze-dried composites had a typical biomimetic network, consisting of collagen fibers and precipitates of nano-sized apatite crystals. The human osteoblast-like cells on the FA-collagen composites exhibited significantly higher proliferation and differentiation (according to alkaline phosphatase activity) than those on the hydroxyapatite-collagen composite. These enhanced osteoblastic cell responses were attributed to the fluorine release and the reduced dissolution rate.

Original languageEnglish
Pages (from-to)2957-2963
Number of pages7
Issue number16
Publication statusPublished - 2005 Jun
Externally publishedYes


  • Biomimetic coprecipitation
  • Cellular responses
  • Collagen
  • Fluorapatite (FA)
  • Stability

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Ceramics and Composites
  • Biomaterials
  • Mechanics of Materials


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