TY - JOUR
T1 - Stabilization of polymer-hydrogel capsules via thiol-disulfide exchange
AU - Chong, Siow Feng
AU - Chandrawati, Rona
AU - Städler, Brigitte
AU - Park, Jeongju
AU - Cho, Jinhan
AU - Wang, Yajun
AU - Jia, Zhongfan
AU - Bulmus, Volga
AU - Davis, Thomas P.
AU - Zelikin, Alexander N.
AU - Caruso, Frank
PY - 2009/11/16
Y1 - 2009/11/16
N2 - Polymer hydrogels are used in diverse biomedical applications including drug delivery and tissue engineering. Among different chemical linkages, the natural and reversible thiol-disulfide interconversion is extensively explored to stabilize hydrogels. The creation of macro-, micro-, and nanoscale disulfide-stabilized hydrogels commonly relies on the use of oxidizing agents that may have a detrimental effect on encapsulated cargo. Herein an oxidization-free approach to create disulfide-stabilized polymer hydrogels via a thiol-disulfide exchange reaction is reported. In particular, thiolated poly(methacrylic acid) is used and the conditions of polymer crosslinking in solution and on colloidal porous and solid microparticles are established. In the latter case, removal of the core particles yields stable, hollow,disulfide-crosslinked hydrogel capsules. Further, a procedure is developed to achieve efficient disulfide crosslinking of multilayered polymer films to obtain stable, liposome-loaded polymer-hydrogel capsules that contain functional enzymatic cargo within the liposomal subcompartments. This approach is envisaged to facilitate the development ofbiomedical applications of hydrogels, specifically those including fragile cargo.
AB - Polymer hydrogels are used in diverse biomedical applications including drug delivery and tissue engineering. Among different chemical linkages, the natural and reversible thiol-disulfide interconversion is extensively explored to stabilize hydrogels. The creation of macro-, micro-, and nanoscale disulfide-stabilized hydrogels commonly relies on the use of oxidizing agents that may have a detrimental effect on encapsulated cargo. Herein an oxidization-free approach to create disulfide-stabilized polymer hydrogels via a thiol-disulfide exchange reaction is reported. In particular, thiolated poly(methacrylic acid) is used and the conditions of polymer crosslinking in solution and on colloidal porous and solid microparticles are established. In the latter case, removal of the core particles yields stable, hollow,disulfide-crosslinked hydrogel capsules. Further, a procedure is developed to achieve efficient disulfide crosslinking of multilayered polymer films to obtain stable, liposome-loaded polymer-hydrogel capsules that contain functional enzymatic cargo within the liposomal subcompartments. This approach is envisaged to facilitate the development ofbiomedical applications of hydrogels, specifically those including fragile cargo.
KW - Capsosomes
KW - Crosslinkers
KW - Hydrogels
KW - Layer-by-layer assembly
KW - Poly(methacrylic acid)
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U2 - 10.1002/smll.200900906
DO - 10.1002/smll.200900906
M3 - Article
C2 - 19771568
AN - SCOPUS:69249235982
SN - 1613-6810
VL - 5
SP - 2601
EP - 2610
JO - Small
JF - Small
IS - 22
ER -