Standing-wave design of a simulated moving bed under a pressure limit for enantioseparation of phenylpropanolamine

Ki Bong Lee, Chim Y. Chin, Yi Xie, Geoffrey B. Cox, Nien Hwa Linda Wang

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)


An improved standing-wave design method is developed for nonlinear simulated moving bed (SMB) systems with significant mass-transfer effects and an operating pressure limit. The design method was verified with rate model simulations and then tested for enantioseparation of phenylpropanolamine. High purity (>99%) and high yield (>99%) were achieved experimentally using a SMB with a pressure limit of 350 psi. The verified design method was used to find the optimal column length that gives the maximum throughput per bed volume. For a given particle size and a pressure limit, the optimal column length falls on the boundary between the masstransfer-limiting region and the pressure-limiting region. If a characteristic dispersion velocity is more than 0.2% of an interstitial velocity, mass-transfer effects must be considered in the design in order to guarantee 99% purity and yield.

Original languageEnglish
Pages (from-to)3249-3267
Number of pages19
JournalIndustrial and Engineering Chemistry Research
Issue number9
Publication statusPublished - 2005 Apr 27
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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