State-of-the-art nanotechnologies used in the development of SARS-CoV-2 biosensors: A review

Dongtak Lee, Taeha Lee, Ji Hye Hong, Hyo Gi Jung, Sang Won Lee, Gyudo Lee, Dae Sung Yoon

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


The coronavirus disease (COVID-19) pandemic has spread to nearly every corner of the globe, significantly impacting economies and societies. Despite advances in detection technologies that target viral pathogens, all countries are facing an unprecedented need to perform biosensing in a rapid, sensitive, selective, and reliable way to deal with global and urgent problems. To date, the reverse transcription-polymerase chain reaction has been the gold-standard method for COVID-19 diagnosis. However, it requires complex facilities and elaborate training and is hampered by limited testing capacity and delayed results. Herein, we review state-of-the-art research into point-of-care biosensors for early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. We include a general description of the nanotechnological techniques used to develop biosensors, along with the latest research into various biosensors for SARS-CoV-2 detection and a summary of their limitations for practical use. Finally, we discuss future perspectives and directions. This critical review offers the biosensor community insight into how to progress the present research, which may streamline the removal of the problems facing rapid and large-scale SARS-CoV-2 screening.

Original languageEnglish
Article number062002
JournalMeasurement Science and Technology
Issue number6
Publication statusPublished - 2022 Jun

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIP) (Nos. NRF-2018M3C1B7020722, NRF-2019R1A2B5B01070617, NRF-2020R1A2C2102262, and 2021R1A4A1028969). This study was also supported by Brain Korea 21 (BK21 FOUR), the Health Fellowship Foundation, a Korea University Grant, and the Korea University Graduate School Junior Fellow Research Grant.

Publisher Copyright:
© 2022 IOP Publishing Ltd.


  • biosensor
  • coronavirus disease
  • early diagnosis
  • point-of-care
  • viral pathogen

ASJC Scopus subject areas

  • Instrumentation
  • Engineering (miscellaneous)
  • Applied Mathematics


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