Static and Dynamic Biomaterial Engineering for Cell Modulation

Hyung Joon Park, Hyunsik Hong, Ramar Thangam, Min Gyo Song, Ju Eun Kim, Eun Hae Jo, Yun Jeong Jang, Won Hyoung Choi, Min Young Lee, Heemin Kang, Kyu Back Lee

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly and indirectly, which invokes various physiological responses in the body. Hence, efficient strategies to modulate cellular responses for a specific purpose have become important for various scientific fields such as biology, pharmacy, and medicine. Among many approaches, the utilization of biomaterials has been studied the most because they can be meticulously engineered to mimic cellular modulatory behavior. For such careful engineering, studies on physical modulation (e.g., ECM topography, stiffness, and wettability) and chemical manipulation (e.g., composition and soluble and surface biosignals) have been actively conducted. At present, the scope of research is being shifted from static (considering only the initial environment and the effects of each element) to biomimetic dynamic (including the concepts of time and gradient) modulation in both physical and chemical manipulations. This review provides an overall perspective on how the static and dynamic biomaterials are actively engineered to modulate targeted cellular responses while highlighting the importance and advance from static modulation to biomimetic dynamic modulation for biomedical applications.

Original languageEnglish
Article number1377
Issue number8
Publication statusPublished - 2022 Apr 1

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • Biomaterial engineering
  • Biomedical engineering
  • Cell modulation
  • Dynamic modulation
  • Static modulation

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Materials Science


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