Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction

Wenyan Xie, Xi Wei, Heemin Kang, Hong Jiang, Zhiqin Chu, Yuan Lin, Yong Hou, Qiang Wei

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to mechanobiology is provided. A biophysical perspective on the state-of-the-art manipulation techniques and novel materials in designing static and dynamic ECM-mimicking biomaterials is taken. In particular, different static and dynamic mechanical cues in regulating cellular mechanosensing and functions are compared. This review to benefit the development of engineering biomechanical systems regulating cell functions is expected.

Original languageEnglish
Article number2204594
JournalAdvanced Science
Volume10
Issue number9
DOIs
Publication statusPublished - 2023 Mar 24

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

Keywords

  • ECM dynamics
  • cellular force
  • engineering biomaterials
  • matrix mechanics
  • mechanotransduction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Chemical Engineering
  • General Materials Science
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • General Engineering
  • General Physics and Astronomy

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