Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

Yong Keun Park, Monica Diez-Silva, Dan Fu, Gabriel Popescu, Wonshik Choi, Ishan Barman, Subra Suresh, Michael S. Feld

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)


We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.

Original languageEnglish
Article number020506
JournalJournal of biomedical optics
Issue number2
Publication statusPublished - 2010

Bibliographical note

Funding Information:
This research was supported by the National Institutes of Health (P41-RR02594-18). Park was supported by a Samsung Scholarship. Diez-Silva and Suresh acknowledge support from the Interdisciplinary Research Group on Infectious Diseases, which is supported by the Singapore-MIT Alliance for Research and Technology and by the National Institutes of Health (1R01HL094270-01A1).


  • Electric field
  • Light scattering
  • Malaria
  • Plasmodium falciparum
  • Red blood cell

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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