Stealth Attack: Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects

Jee Hoon Roh; David M. Holtzman

doi:10.1016/j.neuron.2012.11.018

Stealth Attack: Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects

Jee Hoon Roh, David M. Holtzman

Research output: Contribution to journal › Short survey › peer-review

2 Citations (Scopus)

Abstract

Anti-Aβ antibodies are being developed as potential treatments for Alzheimer's disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron, DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.

Original language	English
Pages (from-to)	859-861
Number of pages	3
Journal	Neuron
Volume	76
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2012.11.018
Publication status	Published - 2012 Dec 6
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2012.11.018

Cite this

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title = "Stealth Attack: Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects",

abstract = "Anti-Aβ antibodies are being developed as potential treatments for Alzheimer's disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron, DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.",

author = "Roh, {Jee Hoon} and Holtzman, {David M.}",

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T1 - Stealth Attack

T2 - Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects

AU - Roh, Jee Hoon

AU - Holtzman, David M.

PY - 2012/12/6

Y1 - 2012/12/6

N2 - Anti-Aβ antibodies are being developed as potential treatments for Alzheimer's disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron, DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.

AB - Anti-Aβ antibodies are being developed as potential treatments for Alzheimer's disease. Some have dose-limiting side effects and many do not robustly remove pre-existing amyloid plaques. In this issue of Neuron, DeMattos et al. (2012) demonstrate that an amyloid plaque-specific antibody removes existing Aβ aggregates without side effects.

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U2 - 10.1016/j.neuron.2012.11.018

DO - 10.1016/j.neuron.2012.11.018

M3 - Short survey

AN - SCOPUS:84872707886

SN - 0896-6273

VL - 76

SP - 859

EP - 861

JO - Neuron

JF - Neuron

IS - 5

ER -

Stealth Attack: Plaque-Specific Antibody Allows for Efficient Aβ Removal without Side Effects

Abstract

ASJC Scopus subject areas

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