Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production

Ki Yong Lee; Eun Ju Jeong; Sang Hyun Sung; Young Choong Kim

Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production

Ki Yong Lee
, Eun Ju Jeong
, Sang Hyun Sung
, Young Choong Kim^*

^*Corresponding author for this work

Korea University (SEJONG)

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 μM.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	Records of Natural Products
Volume	10
Issue number	1
Publication status	Published - 2015 Jan 8

Bibliographical note

Publisher Copyright:
© 2015 ACG Publications. All rights reserved.

Keywords

Alkaloids
BV2 microglia
Lipopolysaccharide
Nitric oxide
Stemona tuberose

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Organic Chemistry

Cite this

@article{e5e0af35a7034d6e8a971ee5f2b5579c,

title = "Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production",

abstract = "A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 μM.",

keywords = "Alkaloids, BV2 microglia, Lipopolysaccharide, Nitric oxide, Stemona tuberose",

author = "Lee, \{Ki Yong\} and Jeong, \{Eun Ju\} and Sung, \{Sang Hyun\} and Kim, \{Young Choong\}",

year = "2015",

month = jan,

day = "8",

language = "English",

volume = "10",

pages = "109--112",

journal = "Records of Natural Products",

issn = "1307-6167",

publisher = "ACG Publications",

number = "1",

}

TY - JOUR

T1 - Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production

AU - Lee, Ki Yong

AU - Jeong, Eun Ju

AU - Sung, Sang Hyun

AU - Kim, Young Choong

PY - 2015/1/8

Y1 - 2015/1/8

N2 - A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 μM.

AB - A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 μM.

KW - Alkaloids

KW - BV2 microglia

KW - Lipopolysaccharide

KW - Nitric oxide

KW - Stemona tuberose

UR - https://www.scopus.com/pages/publications/84938794694

M3 - Article

AN - SCOPUS:84938794694

SN - 1307-6167

VL - 10

SP - 109

EP - 112

JO - Records of Natural Products

JF - Records of Natural Products

IS - 1

ER -

Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this