Stereoselective Synthesis of Anti-HepatitisB Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage

Young Eum Hyun; Hong Rae Kim; Yongseok Choi; Lak Shin Jeong

doi:10.1002/ajoc.201700032

Stereoselective Synthesis of Anti-HepatitisB Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage

Young Eum Hyun, Hong Rae Kim, Yongseok Choi, Lak Shin Jeong

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and Ti^III-mediated regio- and stereoselective epoxide cleavage as key steps.

Original language	English
Journal	Asian Journal of Organic Chemistry
DOIs	https://doi.org/10.1002/ajoc.201700032
Publication status	Accepted/In press - 2017

Keywords

Carbocyclic nucleoside
Entecavir
Hepatitis B
Stereoselective synthesis
Titanium

ASJC Scopus subject areas

Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajoc.201700032

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title = "Stereoselective Synthesis of Anti-HepatitisB Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage",

abstract = "A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and TiIII-mediated regio- and stereoselective epoxide cleavage as key steps.",

keywords = "Carbocyclic nucleoside, Entecavir, Hepatitis B, Stereoselective synthesis, Titanium",

author = "Hyun, {Young Eum} and Kim, {Hong Rae} and Yongseok Choi and Jeong, {Lak Shin}",

year = "2017",

doi = "10.1002/ajoc.201700032",

language = "English",

journal = "Asian Journal of Organic Chemistry",

issn = "2193-5807",

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AU - Hyun, Young Eum

AU - Kim, Hong Rae

AU - Choi, Yongseok

AU - Jeong, Lak Shin

PY - 2017

Y1 - 2017

N2 - A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and TiIII-mediated regio- and stereoselective epoxide cleavage as key steps.

AB - A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and TiIII-mediated regio- and stereoselective epoxide cleavage as key steps.

KW - Carbocyclic nucleoside

KW - Entecavir

KW - Hepatitis B

KW - Stereoselective synthesis

KW - Titanium

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DO - 10.1002/ajoc.201700032

M3 - Article

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JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

ER -

Stereoselective Synthesis of Anti-HepatitisB Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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