2,3-Butanediol is an attractive product for biorefinery due to its various applications and industrial potential. Enterobacter aerogenes is also considered as a major 2,3-butanediol producer. This study is intended to enhance the production of 2,3-butanediol with addition of acetate into the culture media using E. aerogenes ATCC 29007 and to determine the mechanism of improved 2,3-butanediol production. 2,3-Butanediol production was increased by 34.2% with the addition of acetate in batch culture compared to that without acetate in 130 g/L of glucose. This increase was caused by buffering effects and upregulation of the transcription levels of genes involved in 2,3-butanediol production through acetate addition.
Bibliographical noteFunding Information:
This work was supported by the Advanced Biomass R&D Center (ABC-2011-0031360) of Global Frontier Project funded by the Ministry of Science , ICT and Future Planning of Korea. This research was also supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( NRF-2013R1A1A2057887 ).
© 2016 Elsevier Ltd
- Enterobacter aerogenes
- Transcriptional regulation
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology