Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol

Hyun Yong Shin; Jin Young Lee; You Ree Jung; Seung Wook Kim

doi:10.1016/j.biortech.2010.01.095

Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol

Hyun Yong Shin, Jin Young Lee, You Ree Jung, Seung Wook Kim

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation.

Original language	English
Pages (from-to)	4549-4553
Number of pages	5
Journal	Bioresource technology
Volume	101
Issue number	12
DOIs	https://doi.org/10.1016/j.biortech.2010.01.095
Publication status	Published - 2010 Jun

Keywords

Acremonium chrysogenum
Glycerol
Isopenicillin N synthase
Morphological characteristics
Transporter

ASJC Scopus subject areas

Bioengineering
Environmental Engineering
Renewable Energy, Sustainability and the Environment
Waste Management and Disposal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.biortech.2010.01.095

Cite this

@article{987c9c50b7774469b550c0b3d783151b,

title = "Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol",

abstract = "In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation.",

keywords = "Acremonium chrysogenum, Glycerol, Isopenicillin N synthase, Morphological characteristics, Transporter",

author = "Shin, {Hyun Yong} and Lee, {Jin Young} and Jung, {You Ree} and Kim, {Seung Wook}",

year = "2010",

month = jun,

doi = "10.1016/j.biortech.2010.01.095",

language = "English",

volume = "101",

pages = "4549--4553",

journal = "Bioresource technology",

issn = "0960-8524",

publisher = "Elsevier Ltd",

number = "12",

}

TY - JOUR

T1 - Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol

AU - Shin, Hyun Yong

AU - Lee, Jin Young

AU - Jung, You Ree

AU - Kim, Seung Wook

PY - 2010/6

Y1 - 2010/6

N2 - In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation.

AB - In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation.

KW - Acremonium chrysogenum

KW - Glycerol

KW - Isopenicillin N synthase

KW - Morphological characteristics

KW - Transporter

UR - http://www.scopus.com/inward/record.url?scp=77649338443&partnerID=8YFLogxK

U2 - 10.1016/j.biortech.2010.01.095

DO - 10.1016/j.biortech.2010.01.095

M3 - Article

C2 - 20171092

AN - SCOPUS:77649338443

SN - 0960-8524

VL - 101

SP - 4549

EP - 4553

JO - Bioresource technology

JF - Bioresource technology

IS - 12

ER -

Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this