Stimulatory effects of ferulic acid on endurance exercise capacity in mice

Yanghee You, Jeongjin Park, Ho Geun Yoon, Yoo Hyun Lee, Kwontack Hwang, Jeongmin Lee, Kyungmi Kim, Kwang Won Lee, Sangin Shim, Woojin Jun

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Ferulic acid was orally administered to mice in order to investigate its effects on exercise endurance capacity. When a single administration of ferulic acid was given to the mice in an adjustable-current water pool, the duration of exhaustive swimming was longer than that exhibited by the mice in the control group. Also, when the mice were exhaustively exercised for 3 consecutive days, no change in swimming time was found in the ferulic acid-administered group on the final day, and a large decrease in the untreated mice. Administration of ferulic acid efficiently activated the hepatic antioxidative defense system during exercise. The mice that received ferulic acid showed significant increases in the activity of hepatic antioxidant enzymes such as superoxide dismutase, catalase, and glutathione-S-transferase. Furthermore, an increased glutathione level was observed, while the malondialdehyde content was reduced. These results suggest that ferulic acid possesses stimulatory effects that can enhance exercise endurance capacity and reduce fatigue by elevating antioxidative potentials.

Original languageEnglish
Pages (from-to)1392-1397
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Issue number6
Publication statusPublished - 2009

Bibliographical note

Funding Information:
The authors are grateful to the Ministry of Commerce, Industry, and Energy of Korea for financial support.


  • Antioxidation
  • Exercise endurance capacity
  • Fatigue
  • Ferulic acid

ASJC Scopus subject areas

  • General Medicine


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