Strategies for Biosynthesis of C1 Gas-derived Polyhydroxyalkanoates: A review

Jihee Yoon, Min Kyu Oh

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


Biosynthesis of polyhydroxyalkanoates (PHAs) from C1 gases is highly desirable in solving problems such as climate change and microplastic pollution. PHAs are biopolymers synthesized in microbial cells and can be used as alternatives to petroleum-based plastics because of their biodegradability. Because 50% of the cost of PHA production is due to organic carbon sources and salts, the utilization of costless C1 gases as carbon sources is expected to be a promising approach for PHA production. In this review, strategies for PHA production using C1 gases through fermentation and metabolic engineering are discussed. In particular, autotrophs, acetogens, and methanotrophs are strains that can produce PHA from CO2, CO, and CH4. In addition, integrated bioprocesses for the efficient utilization of C1 gases are introduced. Biorefinery processes from C1 gas into bioplastics are prospective strategies with promising potential and feasibility to alleviate environmental issues.

Original languageEnglish
Article number126307
JournalBioresource technology
Publication statusPublished - 2022 Jan


  • Bioplastic
  • Carbon dioxide
  • Carbon monoxide
  • Methane
  • Polyhydroxyalkanoates

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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