Strategy for Stereocomplexation of Polylactide Using O/W Emulsion Blending and Applications as Composite Fillers, Drug Carriers, and Self-Nucleating Agents

Seung Hyuk Im; Seung Hyuk Im; Su Jeong Park; Su Jeong Park; Youngmee Jung; Youngmee Jung; Justin J. Chung; Soo Hyun Kim; Soo Hyun Kim; Soo Hyun Kim

doi:10.1021/acssuschemeng.0c02503

Strategy for Stereocomplexation of Polylactide Using O/W Emulsion Blending and Applications as Composite Fillers, Drug Carriers, and Self-Nucleating Agents

Seung Hyuk Im, Seung Hyuk Im, Su Jeong Park, Su Jeong Park, Youngmee Jung, Youngmee Jung, Justin J. Chung, Soo Hyun Kim, Soo Hyun Kim, Soo Hyun Kim

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Biodegradable polymer polylactide (PLA) can form stereocomplex crystals through racemic blending between poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA). This stereocomplexation could lead to substantially improved mechanical and physical strengths for PLA. Various methods for preparing stereocomplex PLA (sc-PLA) have been studied, e.g., solution blending, melt blending, and supercritical fluid (SCF) technology. However, current methods inevitably have various drawbacks including poor efficiency, usability, and low stereocomplexation reaction speeds. Thus, the aim of this study is to develop a novel strategy using oil-in-water (O/W) emulsion blending to overcome the current limitations of stereocomplexation. Our results indicate that the developed strategy can considerably improve the efficiency and accessibility of stereocomplex crystal formation compared to conventional methods such as solution blending and SCF technology. The O/W emulsion blending method exhibits a stereocomplexation efficiency of up to nearly 99%. Additionally, the sc-PLA produced by O/W emulsion blending can act as filler in PLA composites, leading to improvement of their mechanical properties. In addition, a cancer drug such as fluorouracil (5-FU) could be infiltrated into sc-PLA during stereocomplexation induced by O/W emulsion blending. Furthermore, sc-PLA with 5-FU prepared by the novel method could be added for ISN-polymerization in order to give both a nucleating effect and an anticancer effect. It suggests that sc-PLA prepared by our novel method could act as a stable carrier for secondary molecules as well as nucleating agents.

Original language	English
Pages (from-to)	8752-8761
Number of pages	10
Journal	ACS Sustainable Chemistry and Engineering
Volume	8
Issue number	23
DOIs	https://doi.org/10.1021/acssuschemeng.0c02503
Publication status	Published - 2020 Jun 15

Bibliographical note

Funding Information:
This work was supported by the Korea Institute of Science & Technology (KIST) project (2E30341), the KU-KIST Graduate School of Converging Science and Technology Program, and the Exploratory Research Grant of the Korea University Medicine and Korea Institute of Science and Technology.

Publisher Copyright:
© 2020 American Chemical Society.

Keywords

Drug infiltration
Nucleating agent
O/W emulsion blending
Stereocomplex polylactide
Stereocomplexation

ASJC Scopus subject areas

General Chemistry
Environmental Chemistry
General Chemical Engineering
Renewable Energy, Sustainability and the Environment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acssuschemeng.0c02503

Cite this

Im, S. H., Im, S. H., Park, S. J., Park, S. J., Jung, Y., Jung, Y., Chung, J. J., Kim, S. H., Kim, S. H., & Kim, S. H. (2020). Strategy for Stereocomplexation of Polylactide Using O/W Emulsion Blending and Applications as Composite Fillers, Drug Carriers, and Self-Nucleating Agents. ACS Sustainable Chemistry and Engineering, 8(23), 8752-8761. https://doi.org/10.1021/acssuschemeng.0c02503

Im, SH, Im, SH, Park, SJ, Park, SJ, Jung, Y, Jung, Y, Chung, JJ, Kim, SH, Kim, SH & Kim, SH 2020, 'Strategy for Stereocomplexation of Polylactide Using O/W Emulsion Blending and Applications as Composite Fillers, Drug Carriers, and Self-Nucleating Agents', ACS Sustainable Chemistry and Engineering, vol. 8, no. 23, pp. 8752-8761. https://doi.org/10.1021/acssuschemeng.0c02503

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abstract = "Biodegradable polymer polylactide (PLA) can form stereocomplex crystals through racemic blending between poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA). This stereocomplexation could lead to substantially improved mechanical and physical strengths for PLA. Various methods for preparing stereocomplex PLA (sc-PLA) have been studied, e.g., solution blending, melt blending, and supercritical fluid (SCF) technology. However, current methods inevitably have various drawbacks including poor efficiency, usability, and low stereocomplexation reaction speeds. Thus, the aim of this study is to develop a novel strategy using oil-in-water (O/W) emulsion blending to overcome the current limitations of stereocomplexation. Our results indicate that the developed strategy can considerably improve the efficiency and accessibility of stereocomplex crystal formation compared to conventional methods such as solution blending and SCF technology. The O/W emulsion blending method exhibits a stereocomplexation efficiency of up to nearly 99%. Additionally, the sc-PLA produced by O/W emulsion blending can act as filler in PLA composites, leading to improvement of their mechanical properties. In addition, a cancer drug such as fluorouracil (5-FU) could be infiltrated into sc-PLA during stereocomplexation induced by O/W emulsion blending. Furthermore, sc-PLA with 5-FU prepared by the novel method could be added for ISN-polymerization in order to give both a nucleating effect and an anticancer effect. It suggests that sc-PLA prepared by our novel method could act as a stable carrier for secondary molecules as well as nucleating agents.",

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author = "Im, {Seung Hyuk} and Im, {Seung Hyuk} and Park, {Su Jeong} and Park, {Su Jeong} and Youngmee Jung and Youngmee Jung and Chung, {Justin J.} and Kim, {Soo Hyun} and Kim, {Soo Hyun} and Kim, {Soo Hyun}",

note = "Funding Information: This work was supported by the Korea Institute of Science & Technology (KIST) project (2E30341), the KU-KIST Graduate School of Converging Science and Technology Program, and the Exploratory Research Grant of the Korea University Medicine and Korea Institute of Science and Technology. Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

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AU - Park, Su Jeong

AU - Jung, Youngmee

AU - Chung, Justin J.

AU - Kim, Soo Hyun

N1 - Funding Information: This work was supported by the Korea Institute of Science & Technology (KIST) project (2E30341), the KU-KIST Graduate School of Converging Science and Technology Program, and the Exploratory Research Grant of the Korea University Medicine and Korea Institute of Science and Technology. Publisher Copyright: © 2020 American Chemical Society.

PY - 2020/6/15

Y1 - 2020/6/15

N2 - Biodegradable polymer polylactide (PLA) can form stereocomplex crystals through racemic blending between poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA). This stereocomplexation could lead to substantially improved mechanical and physical strengths for PLA. Various methods for preparing stereocomplex PLA (sc-PLA) have been studied, e.g., solution blending, melt blending, and supercritical fluid (SCF) technology. However, current methods inevitably have various drawbacks including poor efficiency, usability, and low stereocomplexation reaction speeds. Thus, the aim of this study is to develop a novel strategy using oil-in-water (O/W) emulsion blending to overcome the current limitations of stereocomplexation. Our results indicate that the developed strategy can considerably improve the efficiency and accessibility of stereocomplex crystal formation compared to conventional methods such as solution blending and SCF technology. The O/W emulsion blending method exhibits a stereocomplexation efficiency of up to nearly 99%. Additionally, the sc-PLA produced by O/W emulsion blending can act as filler in PLA composites, leading to improvement of their mechanical properties. In addition, a cancer drug such as fluorouracil (5-FU) could be infiltrated into sc-PLA during stereocomplexation induced by O/W emulsion blending. Furthermore, sc-PLA with 5-FU prepared by the novel method could be added for ISN-polymerization in order to give both a nucleating effect and an anticancer effect. It suggests that sc-PLA prepared by our novel method could act as a stable carrier for secondary molecules as well as nucleating agents.

AB - Biodegradable polymer polylactide (PLA) can form stereocomplex crystals through racemic blending between poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA). This stereocomplexation could lead to substantially improved mechanical and physical strengths for PLA. Various methods for preparing stereocomplex PLA (sc-PLA) have been studied, e.g., solution blending, melt blending, and supercritical fluid (SCF) technology. However, current methods inevitably have various drawbacks including poor efficiency, usability, and low stereocomplexation reaction speeds. Thus, the aim of this study is to develop a novel strategy using oil-in-water (O/W) emulsion blending to overcome the current limitations of stereocomplexation. Our results indicate that the developed strategy can considerably improve the efficiency and accessibility of stereocomplex crystal formation compared to conventional methods such as solution blending and SCF technology. The O/W emulsion blending method exhibits a stereocomplexation efficiency of up to nearly 99%. Additionally, the sc-PLA produced by O/W emulsion blending can act as filler in PLA composites, leading to improvement of their mechanical properties. In addition, a cancer drug such as fluorouracil (5-FU) could be infiltrated into sc-PLA during stereocomplexation induced by O/W emulsion blending. Furthermore, sc-PLA with 5-FU prepared by the novel method could be added for ISN-polymerization in order to give both a nucleating effect and an anticancer effect. It suggests that sc-PLA prepared by our novel method could act as a stable carrier for secondary molecules as well as nucleating agents.

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Strategy for Stereocomplexation of Polylactide Using O/W Emulsion Blending and Applications as Composite Fillers, Drug Carriers, and Self-Nucleating Agents

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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