Stricture occurring after endoscopic submucosal dissection for esophageal and gastric tumors

Korean ESD Study Group

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Endoscopic sub mucosal dissection (ESD) is a widely accepted treatment for early gastric and esophageal cancer. Compared to endoscopic mucosal resection, ESD has the advantage of enabling en bloc removal of tumors regardless of their size. However, ESD can result in a large artificial ulcer, which may lead to a considerable deformity. Circumferential mucosal defects of more than three-fourths the esophageal circumference, long longitudinal mucosal defects (>30 mm), and lesions in the upper esophagus are significant risk factors for the development of post-ESD strictures of the esophagus. In the stomach, a circumferential mucosal defects more than three-fourths in extent and longitudinal mucosal defects >5 cm are risk factors of post-ESD stricture. If scheduled early, regular endoscopic balloon dilation is effective in controlling and preventing post-ESD stricture. Moreover, intralesional steroid injections or oral steroids can achieve remission of dysphagia or reduce the need for repeated endoscopic balloon dilation. However, further study is needed to improve the prevention of stricture formation.

Original languageEnglish
Pages (from-to)516-522
Number of pages7
JournalClinical Endoscopy
Issue number6
Publication statusPublished - 2014 Nov 1
Externally publishedYes

Bibliographical note

Funding Information:
Financial support of the FWO Vlaanderen, by a special grant (“Krediet aan navorsers ” no. 31506208) for research on the

Publisher Copyright:
© 2014 Korean Society of Gastrointestinal Endoscopy.


  • Endoscopic submucosal dissection
  • Esophagus
  • Stomach
  • Stricture

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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