TY - JOUR
T1 - Stroke induced by splenectomy in hemoglobin Madrid
T2 - Autopsy clues to the underlying mechanism
AU - Kim, Byung Jo
AU - Park, Kun Woo
AU - Koh, Seong Beom
AU - Kim, Han Kyum
AU - Jung, Hye Lim
AU - Park, Min Kyu
AU - Lee, Dae Hie
PY - 2005/3
Y1 - 2005/3
N2 - Thrombo-embolic events, which can be increased after splenectomy in hemoglobin disorders, can cause potentially lethal complications. Although venous thrombosis has been reported, arterial strokes are rarely reported. A case of stroke in a 52-year-old patient with a previously performed splenectomy for known hemoglobin Madrid, an extremely unstable hemoglobinopathy, led us to investigate the possible causal role of splenectomy. The patient had no history of hypertension, diabetes mellitus, smoking, or other vascular risk factors - but upon autopsy, thrombotic angiopathy was observed in multiple organs, including the lung, liver, kidney, coronary artery and brain. Bone marrow hyperplasia was also observed. A thrombotic middle cerebral artery territory infarction appears to have been caused by chronic recurrent thrombosis, which may have been a result of the splenectomy for unstable hemoglobinopathy. This case supports that splenectomy be strongly considered as an uncommon risk factor for stroke.
AB - Thrombo-embolic events, which can be increased after splenectomy in hemoglobin disorders, can cause potentially lethal complications. Although venous thrombosis has been reported, arterial strokes are rarely reported. A case of stroke in a 52-year-old patient with a previously performed splenectomy for known hemoglobin Madrid, an extremely unstable hemoglobinopathy, led us to investigate the possible causal role of splenectomy. The patient had no history of hypertension, diabetes mellitus, smoking, or other vascular risk factors - but upon autopsy, thrombotic angiopathy was observed in multiple organs, including the lung, liver, kidney, coronary artery and brain. Bone marrow hyperplasia was also observed. A thrombotic middle cerebral artery territory infarction appears to have been caused by chronic recurrent thrombosis, which may have been a result of the splenectomy for unstable hemoglobinopathy. This case supports that splenectomy be strongly considered as an uncommon risk factor for stroke.
KW - Splenectomy
KW - Stroke
KW - Thrombotic angiopathy
KW - Unstable hemoglobinopathy
UR - http://www.scopus.com/inward/record.url?scp=15744391162&partnerID=8YFLogxK
U2 - 10.1097/01.mbc.0000161568.59140.a3
DO - 10.1097/01.mbc.0000161568.59140.a3
M3 - Article
C2 - 15741802
AN - SCOPUS:15744391162
SN - 0957-5235
VL - 16
SP - 141
EP - 144
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 2
ER -