Abstract
Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation-πinteractions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives.
Original language | English |
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Pages (from-to) | 1399-1411 |
Number of pages | 13 |
Journal | JACS Au |
Volume | 1 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2021 Sept 27 |
Bibliographical note
Publisher Copyright:© 2022 American Chemical Society.
Keywords
- antibacterial properties
- bioorganic nanoparticles
- chitin
- guanidinium
- hemostasis
- noncovalent interactions
- surface chemistry
- tissue adhesive
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Physical and Theoretical Chemistry
- Organic Chemistry