Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations

Hyun Joon Chang; Myeongsang Lee; Inchul Baek; Yoonjung Kim; Sungsoo Na

doi:10.1109/NMDC.2016.7777124

Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations

Hyun Joon Chang, Myeongsang Lee, Inchul Baek, Yoonjung Kim, Sungsoo Na

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Ap amyloid protein is representative agent, which is involved in neuro-degenerative diseases. Due to the undegrading characteristics under physiological conditions, understanding the structural characteristics of Aβ amyloid protein in detail is crucial. Many efforts have made on the lowering the structural stabilities of Aβ amyloid protein by decreasing the aromatic residues characteristic and hydrophobic effect. However, there lacks an understanding of Aβ amyloid pair structures in detail. In this work, we provide the structural characteristics of Aβ amyloid pair structures by selective leucine residue mutation on phenylalanine residue (F20L). We also considered the polymorphic feature of F20L Aβ amyloid pair based on NN, CC and NC compositions. Furthermore, we found the structural difference of oligomeric and fibrillar NC F20L Aβ amyloid pair structures in detail.

Original language	English
Title of host publication	Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781509043521
DOIs	https://doi.org/10.1109/NMDC.2016.7777124
Publication status	Published - 2016 Dec 7
Event	11th IEEE Nanotechnology Materials and Devices Conference, NMDC 2016 - Toulouse, France Duration: 2016 Oct 9 → 2016 Oct 12

Publication series

Name	Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings

Other

Other	11th IEEE Nanotechnology Materials and Devices Conference, NMDC 2016
Country/Territory	France
City	Toulouse
Period	16/10/9 → 16/10/12

Bibliographical note

Publisher Copyright:
© 2016 IEEE.

ASJC Scopus subject areas

Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials

Access to Document

10.1109/NMDC.2016.7777124

Cite this

Chang, H. J., Lee, M., Baek, I., Kim, Y., & Na, S. (2016). Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations. In Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings Article 7777124 (Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NMDC.2016.7777124

Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations. / Chang, Hyun Joon; Lee, Myeongsang; Baek, Inchul et al.
Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. 7777124 (Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chang, HJ, Lee, M, Baek, I, Kim, Y & Na, S 2016, Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations. in Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings., 7777124, Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings, Institute of Electrical and Electronics Engineers Inc., 11th IEEE Nanotechnology Materials and Devices Conference, NMDC 2016, Toulouse, France, 16/10/9. https://doi.org/10.1109/NMDC.2016.7777124

Chang HJ, Lee M, Baek I, Kim Y, Na S. Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations. In Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc. 2016. 7777124. (Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings). doi: 10.1109/NMDC.2016.7777124

Chang, Hyun Joon ; Lee, Myeongsang ; Baek, Inchul et al. / Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations. Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. (Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings).

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AB - Ap amyloid protein is representative agent, which is involved in neuro-degenerative diseases. Due to the undegrading characteristics under physiological conditions, understanding the structural characteristics of Aβ amyloid protein in detail is crucial. Many efforts have made on the lowering the structural stabilities of Aβ amyloid protein by decreasing the aromatic residues characteristic and hydrophobic effect. However, there lacks an understanding of Aβ amyloid pair structures in detail. In this work, we provide the structural characteristics of Aβ amyloid pair structures by selective leucine residue mutation on phenylalanine residue (F20L). We also considered the polymorphic feature of F20L Aβ amyloid pair based on NN, CC and NC compositions. Furthermore, we found the structural difference of oligomeric and fibrillar NC F20L Aβ amyloid pair structures in detail.

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Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations

Abstract

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