TY - JOUR
T1 - Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder
T2 - A voxel-based morphometric study
AU - Lee, Junyong
AU - Choi, Sunyoung
AU - Kang, June
AU - Won, Eunsoo
AU - Tae, Woo Suk
AU - Lee, Min Soo
AU - Ham, Byung Joo
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( NRF-2014R1A1A2058864 ).
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/11/30
Y1 - 2017/11/30
N2 - Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I.
AB - Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I.
KW - Bipolar I disorder
KW - Dorsomedial prefrontal cortex
KW - Neuroimaging
KW - Reward circuit
KW - Ventrolateral prefrontal cortex
KW - Ventromedial prefrontal cortex
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=85030120965&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2017.09.013
DO - 10.1016/j.pscychresns.2017.09.013
M3 - Article
C2 - 28963911
AN - SCOPUS:85030120965
SN - 0925-4927
VL - 269
SP - 82
EP - 89
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
ER -
