Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study

Junyong Lee; Sunyoung Choi; June Kang; Eunsoo Won; Woo Suk Tae; Min Soo Lee; Byung Joo Ham

doi:10.1016/j.pscychresns.2017.09.013

Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study

Junyong Lee, Sunyoung Choi, June Kang, Eunsoo Won, Woo Suk Tae, Min Soo Lee^*, Byung Joo Ham

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I.

Original language	English
Pages (from-to)	82-89
Number of pages	8
Journal	Psychiatry Research - Neuroimaging
Volume	269
DOIs	https://doi.org/10.1016/j.pscychresns.2017.09.013
Publication status	Published - 2017 Nov 30

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

Bipolar I disorder
Dorsomedial prefrontal cortex
Neuroimaging
Reward circuit
Ventrolateral prefrontal cortex
Ventromedial prefrontal cortex
Voxel-based morphometry

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2017.09.013

Cite this

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title = "Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study",

abstract = "Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I.",

keywords = "Bipolar I disorder, Dorsomedial prefrontal cortex, Neuroimaging, Reward circuit, Ventrolateral prefrontal cortex, Ventromedial prefrontal cortex, Voxel-based morphometry",

author = "Junyong Lee and Sunyoung Choi and June Kang and Eunsoo Won and Tae, \{Woo Suk\} and Lee, \{Min Soo\} and Ham, \{Byung Joo\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = nov,

day = "30",

doi = "10.1016/j.pscychresns.2017.09.013",

language = "English",

volume = "269",

pages = "82--89",

journal = "Psychiatry Research - Neuroimaging",

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T2 - A voxel-based morphometric study

AU - Lee, Junyong

AU - Choi, Sunyoung

AU - Kang, June

AU - Won, Eunsoo

AU - Tae, Woo Suk

AU - Lee, Min Soo

AU - Ham, Byung Joo

PY - 2017/11/30

Y1 - 2017/11/30

N2 - Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I.

AB - Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I.

KW - Bipolar I disorder

KW - Dorsomedial prefrontal cortex

KW - Neuroimaging

KW - Reward circuit

KW - Ventrolateral prefrontal cortex

KW - Ventromedial prefrontal cortex

KW - Voxel-based morphometry

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M3 - Article

C2 - 28963911

AN - SCOPUS:85030120965

SN - 0925-4927

VL - 269

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EP - 89

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

ER -

Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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