TY - JOUR
T1 - Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis
AU - Park, Hae Chul
AU - Hong, Sung Kook
AU - Kim, Hyung Seok
AU - Kim, Seok Hyung
AU - Yoon, Eun Ja
AU - Kim, Cheol Hee
AU - Miki, Naomasa
AU - Huh, Tae Lin
PY - 2000/1/28
Y1 - 2000/1/28
N2 - The present communication reports the isolation and characterization of three new zebrafish elav/Hu (Kim, C.-H., Ueshima, E., Muraoka, O., Tanaka, H., Yeo, S.-Y., Huh, T.-L. and Miki, N., Zebrafish elav/HuC homologue as a very early neuronal marker. Neurosci. Lett., 216 (1996) 109-112) homologues, HuA, HuD and HuG. While HuA and HuG showed weak and ubiquitous expressions, HuD, as well as HuC, were specifically expressed in the neuronal cells. The first expression of HuD was detectable of the 10-somite stage, that is, several hours later than HuC. After 24 h of embryonic development, although HuD and HuC expressions overlapped overall, the cells expressing HuD were restricted to subsets of the HuC-positive neuronal cells in the brain and spinal cord. These differentially regulated spatial and temporal expression patterns implied distinct roles for HuC and HuD in neuronal determination and neuronal differentiation, respectively. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - The present communication reports the isolation and characterization of three new zebrafish elav/Hu (Kim, C.-H., Ueshima, E., Muraoka, O., Tanaka, H., Yeo, S.-Y., Huh, T.-L. and Miki, N., Zebrafish elav/HuC homologue as a very early neuronal marker. Neurosci. Lett., 216 (1996) 109-112) homologues, HuA, HuD and HuG. While HuA and HuG showed weak and ubiquitous expressions, HuD, as well as HuC, were specifically expressed in the neuronal cells. The first expression of HuD was detectable of the 10-somite stage, that is, several hours later than HuC. After 24 h of embryonic development, although HuD and HuC expressions overlapped overall, the cells expressing HuD were restricted to subsets of the HuC-positive neuronal cells in the brain and spinal cord. These differentially regulated spatial and temporal expression patterns implied distinct roles for HuC and HuD in neuronal determination and neuronal differentiation, respectively. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - HuA
KW - HuC
KW - HuD
KW - HuG
KW - Neural plate
KW - Neuronal determination
KW - Neuronal differentiation
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=0033972751&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(99)00940-4
DO - 10.1016/S0304-3940(99)00940-4
M3 - Article
C2 - 10674626
AN - SCOPUS:0033972751
SN - 0304-3940
VL - 279
SP - 81
EP - 84
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -