Structural heterogeneity of the mammalian polycomb repressor complex in immune regulation

Seok Jin Kang, Taehoon Chun

    Research output: Contribution to journalReview articlepeer-review

    16 Citations (Scopus)

    Abstract

    Epigenetic regulation is mainly mediated by enzymes that can modify the structure of chromatin by altering the structure of DNA or histones. Proteins involved in epigenetic processes have been identified to study the detailed molecular mechanisms involved in the regulation of specific mRNA expression. Evolutionarily well-conserved polycomb group (PcG) proteins can function as transcriptional repressors by the trimethylation of histone H3 at the lysine 27 residue (H3K27me3) and the monoubiquitination of histone H2A at the lysine 119 residue (H2AK119ub). PcG proteins form two functionally distinct protein complexes: polycomb repressor complex 1 (PRC1) and PRC2. In mammals, the structural heterogeneity of each PRC complex is dramatically increased by several paralogs of its subunit proteins. Genetic studies with transgenic mice along with RNA-seq and chromatin immunoprecipitation (ChIP)-seq analyses might be helpful for defining the cell-specific functions of paralogs of PcG proteins. Here, we summarize current knowledge about the immune regulatory role of PcG proteins related to the compositional diversity of each PRC complex and introduce therapeutic drugs that target PcG proteins in hematopoietic malignancy.

    Original languageEnglish
    Pages (from-to)1004-1015
    Number of pages12
    JournalExperimental and Molecular Medicine
    Volume52
    Issue number7
    DOIs
    Publication statusPublished - 2020 Jul 1

    Bibliographical note

    Funding Information:
    This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2019R1A2C2088046) and an intramural research program funded by a Korea University grant (2017).

    Publisher Copyright:
    © 2020, The Author(s).

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Clinical Biochemistry

    Fingerprint

    Dive into the research topics of 'Structural heterogeneity of the mammalian polycomb repressor complex in immune regulation'. Together they form a unique fingerprint.

    Cite this