Structure biology of selective autophagy receptors

Byeong Won Kim, Do Hoon Kwon, Hyun Kyu Song

    Research output: Contribution to journalReview articlepeer-review

    45 Citations (Scopus)

    Abstract

    Autophagy is a process tightly regulated by various autophagy-related proteins. It is generally classified into non-selective and selective autophagy. Whereas non-selective autophagy is triggered when the cell is under starvation, selective autophagy is involved in eliminating dysfunctional organelles, misfolded and/or ubiquitylated proteins, and intracellular pathogens. These components are recognized by autophagy receptors and delivered to phagophores. Several selective autophagy receptors have been identified and characterized. They usually have some common domains, such as LC3-interacting-region (LIR) motif, a specific cargo interacting (ubiquitin-dependent or ubiquitin-independent) domain. Recently, structural data of these autophagy receptors has been described, which provides an insight of their function in the selective autophagic process. In this review, we summarize the most up-to-date findings about the structure-function of autophagy receptors that regulates selective autophagy.

    Original languageEnglish
    Pages (from-to)73-80
    Number of pages8
    JournalBMB reports
    Volume49
    Issue number2
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Autophagy
    • LIR motif
    • Receptor
    • Selective autophagy
    • Ubiquitin binding domain

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

    Fingerprint

    Dive into the research topics of 'Structure biology of selective autophagy receptors'. Together they form a unique fingerprint.

    Cite this