Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.
Bibliographical noteFunding Information:
This work was supported by the Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea , the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT [2018M3A9E2023257], and the institutional program of the Materials Architecturing Research Center of Korea Institute of Science and Technology.
© 2021 American Chemical Society.
- 3D printing
- biodegradable polymers
- block copolymer
ASJC Scopus subject areas
- Polymers and Plastics
- Process Chemistry and Technology
- Organic Chemistry