Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability

Ryung Il Kim; Geonchang Lee; Jung Hyun Lee; Ji Jong Park; Albert S. Lee; Seung Sang Hwang

doi:10.1021/acsapm.1c00860

Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability

Ryung Il Kim
, Geonchang Lee
, Jung Hyun Lee
, Ji Jong Park
, Albert S. Lee^*
, Seung Sang Hwang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.

Original language	English
Pages (from-to)	4708-4716
Number of pages	9
Journal	ACS Applied Polymer Materials
Volume	3
Issue number	9
DOIs	https://doi.org/10.1021/acsapm.1c00860
Publication status	Published - 2021 Sept 10

Bibliographical note

Funding Information:
This work was supported by the Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea [20008734], the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT [2018M3A9E2023257], and the institutional program of the Materials Architecturing Research Center of Korea Institute of Science and Technology.

Publisher Copyright:
© 2021 American Chemical Society.

Keywords

3D printing
biodegradable polymers
bioelastomer
block copolymer
polyurethane

ASJC Scopus subject areas

Polymers and Plastics
Process Chemistry and Technology
Organic Chemistry

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10.1021/acsapm.1c00860

Cite this

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title = "Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability",

abstract = "Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments. ",

keywords = "3D printing, biodegradable polymers, bioelastomer, block copolymer, polyurethane",

author = "Kim, \{Ryung Il\} and Geonchang Lee and Lee, \{Jung Hyun\} and Park, \{Ji Jong\} and Lee, \{Albert S.\} and Hwang, \{Seung Sang\}",

note = "Funding Information: This work was supported by the Fundamental R\&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea [20008734], the National R\&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT [2018M3A9E2023257], and the institutional program of the Materials Architecturing Research Center of Korea Institute of Science and Technology. Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

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doi = "10.1021/acsapm.1c00860",

language = "English",

volume = "3",

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journal = "ACS Applied Polymer Materials",

issn = "2637-6105",

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AU - Kim, Ryung Il

AU - Lee, Geonchang

AU - Lee, Jung Hyun

AU - Park, Ji Jong

AU - Lee, Albert S.

AU - Hwang, Seung Sang

N1 - Funding Information: This work was supported by the Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea [20008734], the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT [2018M3A9E2023257], and the institutional program of the Materials Architecturing Research Center of Korea Institute of Science and Technology. Publisher Copyright: © 2021 American Chemical Society.

PY - 2021/9/10

Y1 - 2021/9/10

N2 - Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.

AB - Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.

KW - 3D printing

KW - biodegradable polymers

KW - bioelastomer

KW - block copolymer

KW - polyurethane

UR - https://www.scopus.com/pages/publications/85114347324

U2 - 10.1021/acsapm.1c00860

DO - 10.1021/acsapm.1c00860

M3 - Article

AN - SCOPUS:85114347324

SN - 2637-6105

VL - 3

SP - 4708

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JO - ACS Applied Polymer Materials

JF - ACS Applied Polymer Materials

IS - 9

ER -

Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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