Structure-property Relationships Reported for the New Drugs Approved in 2022

Research output: Contribution to journalShort surveypeer-review

Abstract

Background: The structure–property relationship illustrates how modifying the chemical structure of a pharmaceutical compound influences its absorption, distribution, metabolism, excretion, and other related properties. Understanding structure–property relationships of clinically approved drugs could provide useful information for drug design and optimization strategies. Method: Among new drugs approved around the world in 2022, including 37 in the US, structure– property relationships of seven drugs were compiled from medicinal chemistry literature, in which detailed pharmacokinetic and/or physicochemical properties were disclosed not only for the final drug but also for its key analogues generated during drug development. Results: The discovery campaigns for these seven drugs demonstrate extensive design and optimization efforts to identify suitable candidates for clinical development. Several strategies have been successfully employed, such as attaching a solubilizing group, bioisosteric replacement, and deuterium incorporation, resulting in new compounds with enhanced physicochemical and pharmacokinetic properties. Conclusion: The structure-property relationships hereby summarized illustrate how proper structural modifications could successfully improve the overall drug-like properties. The structure–property relationships of clinically approved drugs are expected to continue to provide valuable references and guides for the development of future drugs.

Original languageEnglish
Pages (from-to)330-340
Number of pages11
JournalMini-Reviews in Medicinal Chemistry
Volume24
Issue number3
DOIs
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© 2024 Bentham Science Publishers.

Keywords

  • Structure-property relationship
  • candidate selection
  • deuterium incorporation
  • drug discovery
  • lead optimization
  • solubilizing group

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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