Diastereoselective alkylation of enolate dianion of (S)-4-carboethyoxymethyl-2-oxazolidinone has been studied. The increased anti-selectivity in the presence of HMPA was explained by stereoelectronic effect of the electron-rich nitrogen atom of the oxazolidinone amidate.
|Number of pages||4|
|Publication status||Published - 1996 Aug 5|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry