Studies on the synthesis and in vitro antitumor activity of the isoquinolone derivatives

Seung Hoon Cheon; Joon Yeol Lee; Byung Ho Chung; Bo Gil Choi; Won Jea Cho; Tae Sung Kim

doi:10.1007/BF02976543

Studies on the synthesis and in vitro antitumor activity of the isoquinolone derivatives

Seung Hoon Cheon, Joon Yeol Lee, Byung Ho Chung, Bo Gil Choi, Won Jea Cho, Tae Sung Kim

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

3-Arylisoquinolin-1(2H)-ones (2) are possible bioisosteres of the 5-[4′-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1) which is in clinical evaluation for the treatment of cancer. Structure-activity relationship studies of 3-arylisoquinolin-1(2H)-ones (2) led to the synthesis of 3-arylquinolin-2(1H)-ones (3). A number of 3-phenyl substituted quinolin-2(1H)-ones were synthesized and tested for their in vitro antitumor activity against four different human tumor cell lines and 3-phenyl-N-benzyl-3,4-dihydroquinolin-2(1H)-one (12) showed the most potent activity.

Original language	English
Pages (from-to)	179-183
Number of pages	5
Journal	Archives of pharmacal research
Volume	22
Issue number	2
DOIs	https://doi.org/10.1007/BF02976543
Publication status	Published - 1999 Apr

Bibliographical note

Funding Information:
This paper was supported by NON DIRECTED RESEARCH FUND, Korea Research Foundation, 1997 and it was greatly appreciated.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

3-Arylisoquinolin-1-ones
3-Arylquinolin-2-ones
Antitumor
Cytotoxicity

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02976543

Cite this

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title = "Studies on the synthesis and in vitro antitumor activity of the isoquinolone derivatives",

abstract = "3-Arylisoquinolin-1(2H)-ones (2) are possible bioisosteres of the 5-[4′-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1) which is in clinical evaluation for the treatment of cancer. Structure-activity relationship studies of 3-arylisoquinolin-1(2H)-ones (2) led to the synthesis of 3-arylquinolin-2(1H)-ones (3). A number of 3-phenyl substituted quinolin-2(1H)-ones were synthesized and tested for their in vitro antitumor activity against four different human tumor cell lines and 3-phenyl-N-benzyl-3,4-dihydroquinolin-2(1H)-one (12) showed the most potent activity.",

keywords = "3-Arylisoquinolin-1-ones, 3-Arylquinolin-2-ones, Antitumor, Cytotoxicity",

author = "Cheon, {Seung Hoon} and Lee, {Joon Yeol} and Chung, {Byung Ho} and Choi, {Bo Gil} and Cho, {Won Jea} and Kim, {Tae Sung}",

note = "Funding Information: This paper was supported by NON DIRECTED RESEARCH FUND, Korea Research Foundation, 1997 and it was greatly appreciated. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1999",

month = apr,

doi = "10.1007/BF02976543",

language = "English",

volume = "22",

pages = "179--183",

journal = "Archives of pharmacal research",

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AU - Cheon, Seung Hoon

AU - Lee, Joon Yeol

AU - Chung, Byung Ho

AU - Choi, Bo Gil

AU - Cho, Won Jea

AU - Kim, Tae Sung

N1 - Funding Information: This paper was supported by NON DIRECTED RESEARCH FUND, Korea Research Foundation, 1997 and it was greatly appreciated. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1999/4

Y1 - 1999/4

N2 - 3-Arylisoquinolin-1(2H)-ones (2) are possible bioisosteres of the 5-[4′-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1) which is in clinical evaluation for the treatment of cancer. Structure-activity relationship studies of 3-arylisoquinolin-1(2H)-ones (2) led to the synthesis of 3-arylquinolin-2(1H)-ones (3). A number of 3-phenyl substituted quinolin-2(1H)-ones were synthesized and tested for their in vitro antitumor activity against four different human tumor cell lines and 3-phenyl-N-benzyl-3,4-dihydroquinolin-2(1H)-one (12) showed the most potent activity.

AB - 3-Arylisoquinolin-1(2H)-ones (2) are possible bioisosteres of the 5-[4′-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1) which is in clinical evaluation for the treatment of cancer. Structure-activity relationship studies of 3-arylisoquinolin-1(2H)-ones (2) led to the synthesis of 3-arylquinolin-2(1H)-ones (3). A number of 3-phenyl substituted quinolin-2(1H)-ones were synthesized and tested for their in vitro antitumor activity against four different human tumor cell lines and 3-phenyl-N-benzyl-3,4-dihydroquinolin-2(1H)-one (12) showed the most potent activity.

KW - 3-Arylisoquinolin-1-ones

KW - 3-Arylquinolin-2-ones

KW - Antitumor

KW - Cytotoxicity

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JF - Archives of pharmacal research

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Studies on the synthesis and in vitro antitumor activity of the isoquinolone derivatives

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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