TY - JOUR
T1 - Suicidal ideation among postmenopausal women on hormone replacement therapy
T2 - The Korean National Health and Nutrition Examination Survey (KNHANES V) from 2010 to 2012
AU - Lee, Ji Yoon
AU - Park, Yong Kyu
AU - Cho, Kyung-Hwan
AU - Kim, Seon Mee
AU - Choi, Youn Seon
AU - Kim, Do-Hoon
AU - Nam, Ga Eun
AU - Han, Kyung Do
AU - Kim, Yang-Hyun
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background Suicide is a major public health problem around the world. Some studies have found that hormone replacement therapy (HRT) is associated with depression in postmenopausal women. Depression is a well-known risk factor for suicide; therefore, we investigated the relationship between HRT and suicidal ideation in postmenopausal Korean women. Methods We included 2286 postmenopausal women with or without HRT from the Korean National Health and Nutrition Examination Survey 2010-2012. The use and duration of HRT and mental health status, including stress, depressive mood, and suicidal ideation and attempts, were assessed by self-report questionnaires. Results The proportion of participants with depressive mood and suicidal ideation was higher in the HRT group than the non-HRT group (all p values<0.05). As the duration of HRT increased, the percentage of participants with suicidal ideation increased (p for trend=0.006). After adjusting for all covariates, the odds ratio (95% confidence intervals) for suicidal ideation was 1.742 (1.223-2.482) in the women with HRT, compared to women without HRT. HRT duration longer than 10 years was associated with suicidal ideation (odds ratio=2.089 and 95% confidence intervals=1.069-4.084). Limitations The cross-sectional design, a possibility of incorrect answer about menopausal status, and no assessment of the type of HRT are the main limitations of this study. Conclusion Postmenopausal women receiving HRT, especially for more than 10 years, showed increased suicidal ideation compared with postmenopausal women without HRT. Physicians should pay attention to mood symptoms and suicidal ideation in postmenopausal women with HRT.
AB - Background Suicide is a major public health problem around the world. Some studies have found that hormone replacement therapy (HRT) is associated with depression in postmenopausal women. Depression is a well-known risk factor for suicide; therefore, we investigated the relationship between HRT and suicidal ideation in postmenopausal Korean women. Methods We included 2286 postmenopausal women with or without HRT from the Korean National Health and Nutrition Examination Survey 2010-2012. The use and duration of HRT and mental health status, including stress, depressive mood, and suicidal ideation and attempts, were assessed by self-report questionnaires. Results The proportion of participants with depressive mood and suicidal ideation was higher in the HRT group than the non-HRT group (all p values<0.05). As the duration of HRT increased, the percentage of participants with suicidal ideation increased (p for trend=0.006). After adjusting for all covariates, the odds ratio (95% confidence intervals) for suicidal ideation was 1.742 (1.223-2.482) in the women with HRT, compared to women without HRT. HRT duration longer than 10 years was associated with suicidal ideation (odds ratio=2.089 and 95% confidence intervals=1.069-4.084). Limitations The cross-sectional design, a possibility of incorrect answer about menopausal status, and no assessment of the type of HRT are the main limitations of this study. Conclusion Postmenopausal women receiving HRT, especially for more than 10 years, showed increased suicidal ideation compared with postmenopausal women without HRT. Physicians should pay attention to mood symptoms and suicidal ideation in postmenopausal women with HRT.
KW - Hormone replacement therapy
KW - Korean National Health and Nutrition Examination Survey
KW - Postmenopausal women
KW - Suicidal ideation
UR - http://www.scopus.com/inward/record.url?scp=84943530056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943530056&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2015.09.068
DO - 10.1016/j.jad.2015.09.068
M3 - Review article
C2 - 26451506
AN - SCOPUS:84943530056
SN - 0165-0327
VL - 189
SP - 214
EP - 219
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -