TY - JOUR
T1 - Suitable Whole Blood Levels 2 Hours After Neoral in Liver Transplant Patients
T2 - Experiences at a Single Center
AU - Kim, K. H.
AU - Lee, S. G.
AU - Lee, Y. J.
AU - Park, K. M.
AU - Hwang, S.
AU - Ahn, C. S.
AU - Moon, D. B.
AU - Ha, T. Y.
AU - Song, K. W.
AU - Kim, D. S.
AU - Jung, D. H.
AU - Kim, B. S.
AU - Moon, K. M.
AU - Lee, H. J.
AU - Park, J. I.
AU - Ryu, J. H.
N1 - Funding Information:
Supported by a grant from Novartis Pharmaceuticals.
PY - 2006/11
Y1 - 2006/11
N2 - Whole blood levels 2 hours after Neoral (C2) administration were observed to correlate better with area under the curve (AUC0-4) than trough levels (C0), suggesting that C2 may be the best single time point predictor of Neoral absorption. Owing to concerns about drug toxicity due to excessive immunosuppression, C2 adjustments to target blood levels may represent an advance. The present study measured C2 and levels to determine which correlated more closely with AUC0-4. Methods: Between August 2003 and July 2004, 40 adult liver transplantations were performed in our center. All patients received Neoral twice daily. They were maintained at a C0 level of about 200 ng/mL. C0 levels were measured daily. C2 levels were estimated on postoperative days 3, 5, 7, 14, and 28. AUC0-4 performed on postoperative days 3, 7, and 28 was calculated using the trapezoidal rule. Results: The mean AUC0-4, C0, C1, C2, C3, and C4 were 1100.3 ± 484.8 ng/mL, 197.1 ± 84.7 ng/mL, 240.7 ± 166.2 ng/mL, 307.8 ± 162.6 ng/mL, 302.8 ± 138.9 ng/mL, and 300.3 ± 142.8 ng/mL, respectively. C2 correlated with AUC0-4 (R2 = 0.868: P < .05) better than C0 (R2 = 0.245: P < .05), C1 (R2 = 0.604: P < .05), or C4 (R2 = 0.583: P < .05). Conclusions: Neoral dose monitoring according to a mean C2 range of 307.8 ± 162.6 ng/mL correlated better with AUC0-4. Further studies are required to determine suitable C2 levels in liver transplant patients.
AB - Whole blood levels 2 hours after Neoral (C2) administration were observed to correlate better with area under the curve (AUC0-4) than trough levels (C0), suggesting that C2 may be the best single time point predictor of Neoral absorption. Owing to concerns about drug toxicity due to excessive immunosuppression, C2 adjustments to target blood levels may represent an advance. The present study measured C2 and levels to determine which correlated more closely with AUC0-4. Methods: Between August 2003 and July 2004, 40 adult liver transplantations were performed in our center. All patients received Neoral twice daily. They were maintained at a C0 level of about 200 ng/mL. C0 levels were measured daily. C2 levels were estimated on postoperative days 3, 5, 7, 14, and 28. AUC0-4 performed on postoperative days 3, 7, and 28 was calculated using the trapezoidal rule. Results: The mean AUC0-4, C0, C1, C2, C3, and C4 were 1100.3 ± 484.8 ng/mL, 197.1 ± 84.7 ng/mL, 240.7 ± 166.2 ng/mL, 307.8 ± 162.6 ng/mL, 302.8 ± 138.9 ng/mL, and 300.3 ± 142.8 ng/mL, respectively. C2 correlated with AUC0-4 (R2 = 0.868: P < .05) better than C0 (R2 = 0.245: P < .05), C1 (R2 = 0.604: P < .05), or C4 (R2 = 0.583: P < .05). Conclusions: Neoral dose monitoring according to a mean C2 range of 307.8 ± 162.6 ng/mL correlated better with AUC0-4. Further studies are required to determine suitable C2 levels in liver transplant patients.
UR - http://www.scopus.com/inward/record.url?scp=33750931023&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2006.08.148
DO - 10.1016/j.transproceed.2006.08.148
M3 - Article
C2 - 17112877
AN - SCOPUS:33750931023
SN - 0041-1345
VL - 38
SP - 2971
EP - 2973
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 9
ER -