Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Sung Bong Kim; Yi Zhang; Sang Min Won; Amay J. Bandodkar; Yurina Sekine; Yeguang Xue; Jahyun Koo; Sean W. Harshman; Jennifer A. Martin; Jeong Min Park; Tyler R. Ray; Kaitlyn E. Crawford; Kyu Tae Lee; Jungil Choi; Rhonda L. Pitsch; Claude C. Grigsby; Adam J. Strang; Yu Yu Chen; Shuai Xu; Jeonghyun Kim; Ahyeon Koh; Jeong Sook Ha; Yonggang Huang; Seung Wook Kim; John A. Rogers

doi:10.1002/smll.201703334

Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Sung Bong Kim, Yi Zhang, Sang Min Won, Amay J. Bandodkar, Yurina Sekine, Yeguang Xue, Jahyun Koo, Sean W. Harshman, Jennifer A. Martin, Jeong Min Park, Tyler R. Ray, Kaitlyn E. Crawford, Kyu Tae Lee, Jungil Choi, Rhonda L. Pitsch, Claude C. Grigsby, Adam J. Strang, Yu Yu Chen, Shuai Xu, Jeonghyun KimAhyeon Koh, Jeong Sook Ha, Yonggang Huang, Seung Wook Kim, John A. Rogers

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.

Original language	English
Article number	1703334
Journal	Small
Volume	14
Issue number	12
DOIs	https://doi.org/10.1002/smll.201703334
Publication status	Published - 2018 Mar 22

Bibliographical note

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

microfluidics
perspiration
super absorbent polymer
sweat chloride

ASJC Scopus subject areas

Biotechnology
General Chemistry
Biomaterials
General Materials Science
Engineering (miscellaneous)

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Kim, S. B., Zhang, Y., Won, S. M., Bandodkar, A. J., Sekine, Y., Xue, Y., Koo, J., Harshman, S. W., Martin, J. A., Park, J. M., Ray, T. R., Crawford, K. E., Lee, K. T., Choi, J., Pitsch, R. L., Grigsby, C. C., Strang, A. J., Chen, Y. Y., Xu, S., ... Rogers, J. A. (2018). Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. Small, 14(12), Article 1703334. https://doi.org/10.1002/smll.201703334

Kim, SB, Zhang, Y, Won, SM, Bandodkar, AJ, Sekine, Y, Xue, Y, Koo, J, Harshman, SW, Martin, JA, Park, JM, Ray, TR, Crawford, KE, Lee, KT, Choi, J, Pitsch, RL, Grigsby, CC, Strang, AJ, Chen, YY, Xu, S, Kim, J, Koh, A, Ha, JS, Huang, Y, Kim, SW & Rogers, JA 2018, 'Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics', Small, vol. 14, no. 12, 1703334. https://doi.org/10.1002/smll.201703334

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abstract = "This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.",

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AU - Sekine, Yurina

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AU - Xu, Shuai

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AU - Koh, Ahyeon

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AU - Rogers, John A.

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Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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