Supramolecular Two-Dimensional Systems and Their Biological Applications

Taeyeon Kim, Jung Yeon Park, Jiwon Hwang, Gunhee Seo, Yongju Kim

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Various biological systems rely on the supramolecular assembly of biomolecules through noncovalent bonds for performing sophisticated functions. In particular, cell membranes, which are 2D structures in biological systems, have various characteristics such as a large surface, flexibility, and molecule-recognition ability. Supramolecular 2D materials based on biological systems provide a novel perspective for the development of functional 2D materials. The physical and chemical properties of 2D structures, attributed to their large surface area, can enhance the sensitivity of the detection of target molecules, molecular loading, and bioconjugation efficiency, suggesting the potential utility of functional 2D materials as candidates for biological systems. Although several types of studies on supramolecular 2D materials have been reported, supramolecular biofunctional 2D materials have not been reviewed previously. In this regard, the current advances in 2D material development using molecular assembly are discussed with respect to the rational design of self-assembling aromatic amphiphiles, the formation of 2D structures, and the biological applications of functional 2D materials.

Original languageEnglish
Article number2002405
JournalAdvanced Materials
Issue number51
Publication statusPublished - 2020 Dec 22


  • 2D materials
  • aromatic amphiphiles
  • biological functions
  • lateral interactions
  • supramolecules

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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