Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres

Sangyeop Lee, Hyangah Chon, Moonkwon Lee, Jaebum Choo, Soon Young Shin, Young Han Lee, Im Joo Rhyu, Sang Wook Son, Chil Hwan Oh

Research output: Contribution to journalArticlepeer-review

173 Citations (Scopus)

Abstract

Antibody-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells.

Original languageEnglish
Pages (from-to)2260-2263
Number of pages4
JournalBiosensors and Bioelectronics
Volume24
Issue number7
DOIs
Publication statusPublished - 2009 Mar 15

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (grant numbers R01-2007-000-20238-0 and R11-2008-044-01002-0), the National Cancer Center of Korea (grant number 0620400-1) and the Seoul Research and Business Development Program (grant number 10574).

Keywords

  • Cancer marker
  • Cellular imaging
  • Hollow gold nanosphere
  • Homogeneous sensing probe
  • Surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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