Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min Woong Hwang, Joon Yong Bae, Jun Heo, Eun Joo Lim, Won Seok Seok, Hee Jin Cheong, Joon Young Song, Woo Joo Kim, Man Seong Park

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


During the 2009-2011 influenza seasons, 10. 26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

Original languageEnglish
Pages (from-to)1067-1070
Number of pages4
JournalJournal of Microbiology
Issue number6
Publication statusPublished - 2012 Dec
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by grants from the Korea healthcare technology R&D project of the Ministry of Health & Welfare‚ Republic of Korea (Grants No. A103001, A084411), Korea Centers for Disease Control and Prevention (2010-E43002-00) and Hallym University, Specialization Fund (HRF-S-41). We would like to thank Saem Shin and Sulhwa Jung for technical assistance.


  • influenza
  • neuraminidase
  • oseltamivir

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology


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