Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

Sehee Park; Jin Il Kim; Ilseob Lee; Sangmoo Lee; Min Woong Hwang; Joon Yong Bae; Jun Heo; Eun Joo Lim; Won Seok Seok; Hee Jin Cheong; Joon Young Song; Woo Joo Kim; Man Seong Park

doi:10.1007/s12275-012-2541-3

Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min Woong Hwang, Joon Yong Bae, Jun Heo, Eun Joo Lim, Won Seok Seok, Hee Jin Cheong, Joon Young Song, Woo Joo Kim, Man Seong Park

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

During the 2009-2011 influenza seasons, 10. 26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

Original language	English
Pages (from-to)	1067-1070
Number of pages	4
Journal	Journal of Microbiology
Volume	50
Issue number	6
DOIs	https://doi.org/10.1007/s12275-012-2541-3
Publication status	Published - 2012 Dec
Externally published	Yes

Keywords

influenza
neuraminidase
oseltamivir

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology

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10.1007/s12275-012-2541-3

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@article{a90c79f02aa44b6fbb352c9bc46922c8,

title = "Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011",

abstract = "During the 2009-2011 influenza seasons, 10. 26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.",

keywords = "influenza, neuraminidase, oseltamivir",

author = "Sehee Park and Kim, {Jin Il} and Ilseob Lee and Sangmoo Lee and Hwang, {Min Woong} and Bae, {Joon Yong} and Jun Heo and Lim, {Eun Joo} and Seok, {Won Seok} and Cheong, {Hee Jin} and Song, {Joon Young} and Kim, {Woo Joo} and Park, {Man Seong}",

note = "Funding Information: This study was supported by grants from the Korea healthcare technology R&D project of the Ministry of Health & Welfare‚ Republic of Korea (Grants No. A103001, A084411), Korea Centers for Disease Control and Prevention (2010-E43002-00) and Hallym University, Specialization Fund (HRF-S-41). We would like to thank Saem Shin and Sulhwa Jung for technical assistance.",

year = "2012",

month = dec,

doi = "10.1007/s12275-012-2541-3",

language = "English",

volume = "50",

pages = "1067--1070",

journal = "Journal of Microbiology",

issn = "1225-8873",

publisher = "Microbiological Society of Korea",

number = "6",

}

TY - JOUR

T1 - Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

AU - Park, Sehee

AU - Kim, Jin Il

AU - Lee, Ilseob

AU - Lee, Sangmoo

AU - Hwang, Min Woong

AU - Bae, Joon Yong

AU - Heo, Jun

AU - Lim, Eun Joo

AU - Seok, Won Seok

AU - Cheong, Hee Jin

AU - Song, Joon Young

AU - Kim, Woo Joo

AU - Park, Man Seong

N1 - Funding Information: This study was supported by grants from the Korea healthcare technology R&D project of the Ministry of Health & Welfare‚ Republic of Korea (Grants No. A103001, A084411), Korea Centers for Disease Control and Prevention (2010-E43002-00) and Hallym University, Specialization Fund (HRF-S-41). We would like to thank Saem Shin and Sulhwa Jung for technical assistance.

PY - 2012/12

Y1 - 2012/12

N2 - During the 2009-2011 influenza seasons, 10. 26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

AB - During the 2009-2011 influenza seasons, 10. 26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

KW - influenza

KW - neuraminidase

KW - oseltamivir

UR - http://www.scopus.com/inward/record.url?scp=84871800151&partnerID=8YFLogxK

U2 - 10.1007/s12275-012-2541-3

DO - 10.1007/s12275-012-2541-3

M3 - Article

C2 - 23274998

AN - SCOPUS:84871800151

SN - 1225-8873

VL - 50

SP - 1067

EP - 1070

JO - Journal of Microbiology

JF - Journal of Microbiology

IS - 6

ER -

Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009-2011

Abstract

Keywords

ASJC Scopus subject areas

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