Sustainable production of polyhydroxybutyrate from autotrophs using CO2 as feedstock: Challenges and opportunities

Ranjna Sirohi, Jeong Seop Lee, Byung Sun Yu, Hyejin Roh, Sang Jun Sim

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Due to industrialization and rapid increase in world population, the global energy consumption has increased dramatically. As a consequence, there is increased consumption of fossil fuels, leading to a rapid increase in CO2 concentration in the atmosphere. This accumulated CO2 can be efficiently used by autotrophs as a carbon source to produce chemicals and biopolymers. There has been increasing attention on the production of polyhydroxybutyrate (PHB), a biopolymer, with focus on reducing the production cost. For this, cheaper renewable feedstocks, molecular tools, including metabolic and genetic engineering have been explored to improve microbial strains along with process engineering aspects for scale-up of PHB production. This review discusses the recent advents on the utilization of CO2 as feedstock especially by engineered autotrophs, for sustainable production of PHB. The review also discusses the innovations in cultivation technology and process monitoring while understanding the underlying mechanisms for CO2 to biopolymer conversion.

Original languageEnglish
Article number125751
JournalBioresource technology
Publication statusPublished - 2021 Dec

Bibliographical note

Funding Information:
This work was supported by “Carbon to X Project” (#2020M3H7A1098295), the National Research Foundation (NRF) funded by the Ministry of Science and ICT, Republic of Korea, a grant (# NRF-2019R1A2C3009821/2020R1A5A1018052) from the National Research Foundation of Korea (NRF).

Publisher Copyright:
© 2021 Elsevier Ltd


  • Autotrophs
  • Cyanobacteria
  • Metabolic engineering
  • Microalgae
  • Polyhydroxybutyrate

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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