Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

Seil Jang; Daeyoung Oh; Yeunkum Lee; Eric Hosy; Hyewon Shin; Christoph Van Riesen; Daniel Whitcomb; Julia M. Warburton; Jihoon Jo; Doyoun Kim; Sun Gyun Kim; Seung Min Um; Seok Kyu Kwon; Myoung Hwan Kim; Junyeop Daniel Roh; Jooyeon Woo; Heejung Jun; Dongmin Lee; Won Mah; Hyun Kim; Bong Kiun Kaang; Kwangwook Cho; Jeong Seop Rhee; Daniel Choquet; Eunjoon Kim

doi:10.1038/nn.4176

Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

Seil Jang, Daeyoung Oh, Yeunkum Lee, Eric Hosy, Hyewon Shin, Christoph Van Riesen, Daniel Whitcomb, Julia M. Warburton, Jihoon Jo, Doyoun Kim, Sun Gyun Kim, Seung Min Um, Seok Kyu Kwon, Myoung Hwan Kim, Junyeop Daniel Roh, Jooyeon Woo, Heejung Jun, Dongmin Lee, Won Mah, Hyun KimBong Kiun Kaang, Kwangwook Cho, Jeong Seop Rhee, Daniel Choquet, Eunjoon Kim

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43 Citations (Scopus)

Abstract

Synaptic adhesion molecules regulate synapse development and plasticity through mechanisms that include trans-synaptic adhesion and recruitment of diverse synaptic proteins. We found that the immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs). IgSF11 required PSD-95 binding for its excitatory synaptic localization. In addition, IgSF11 stabilized synaptic AMPARs, as determined by IgSF11 knockdown-induced suppression of AMPAR-mediated synaptic transmission and increased surface mobility of AMPARs, measured by high-throughput, single-molecule tracking. IgSF11 deletion in mice led to the suppression of AMPAR-mediated synaptic transmission in the dentate gyrus and long-term potentiation in the CA1 region of the hippocampus. IgSF11 did not regulate the functional characteristics of AMPARs, including desensitization, deactivation or recovery. These results suggest that IgSF11 regulates excitatory synaptic transmission and plasticity through its tripartite interactions with PSD-95 and AMPARs.

Original language	English
Pages (from-to)	84-93
Number of pages	10
Journal	Nature Neuroscience
Volume	19
Issue number	1
DOIs	https://doi.org/10.1038/nn.4176
Publication status	Published - 2015 Dec 29

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Publisher Copyright:
© 2016 Nature America, Inc.

ASJC Scopus subject areas

General Neuroscience

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Jang, S., Oh, D., Lee, Y., Hosy, E., Shin, H., Van Riesen, C., Whitcomb, D., Warburton, J. M., Jo, J., Kim, D., Kim, S. G., Um, S. M., Kwon, S. K., Kim, M. H., Roh, J. D., Woo, J., Jun, H., Lee, D., Mah, W., ... Kim, E. (2015). Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Nature Neuroscience, 19(1), 84-93. https://doi.org/10.1038/nn.4176

Jang, S, Oh, D, Lee, Y, Hosy, E, Shin, H, Van Riesen, C, Whitcomb, D, Warburton, JM, Jo, J, Kim, D, Kim, SG, Um, SM, Kwon, SK, Kim, MH, Roh, JD, Woo, J, Jun, H, Lee, D, Mah, W, Kim, H, Kaang, BK, Cho, K, Rhee, JS, Choquet, D & Kim, E 2015, 'Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity', Nature Neuroscience, vol. 19, no. 1, pp. 84-93. https://doi.org/10.1038/nn.4176

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abstract = "Synaptic adhesion molecules regulate synapse development and plasticity through mechanisms that include trans-synaptic adhesion and recruitment of diverse synaptic proteins. We found that the immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs). IgSF11 required PSD-95 binding for its excitatory synaptic localization. In addition, IgSF11 stabilized synaptic AMPARs, as determined by IgSF11 knockdown-induced suppression of AMPAR-mediated synaptic transmission and increased surface mobility of AMPARs, measured by high-throughput, single-molecule tracking. IgSF11 deletion in mice led to the suppression of AMPAR-mediated synaptic transmission in the dentate gyrus and long-term potentiation in the CA1 region of the hippocampus. IgSF11 did not regulate the functional characteristics of AMPARs, including desensitization, deactivation or recovery. These results suggest that IgSF11 regulates excitatory synaptic transmission and plasticity through its tripartite interactions with PSD-95 and AMPARs.",

author = "Seil Jang and Daeyoung Oh and Yeunkum Lee and Eric Hosy and Hyewon Shin and {Van Riesen}, Christoph and Daniel Whitcomb and Warburton, {Julia M.} and Jihoon Jo and Doyoun Kim and Kim, {Sun Gyun} and Um, {Seung Min} and Kwon, {Seok Kyu} and Kim, {Myoung Hwan} and Roh, {Junyeop Daniel} and Jooyeon Woo and Heejung Jun and Dongmin Lee and Won Mah and Hyun Kim and Kaang, {Bong Kiun} and Kwangwook Cho and Rhee, {Jeong Seop} and Daniel Choquet and Eunjoon Kim",

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AU - Kaang, Bong Kiun

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Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

Abstract

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